くすりのしおり

Injection
Revised: 7/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Istodax Injection 10mg
 Active ingredient:
Romidepsin
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine inhibits histone deacetylases to suppress tumor cell proliferation.
It is usually used to treat relapsed/refractory peripheral T cell lymphoma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have myelosuppression, infection, or hepatic disorder.
    If you have risk of QT-interval prolongation or have a history of QT-interval prolongation.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, administer by intravenous infusion over 4 hours on Days 1, 8, and 15, followed by a medicine cessation period of Days 16 to 28. This 28-day period is counted as 1 treatment cycle and repeat this cycle.
  • Ask the doctor about the treatment span.

Precautions while taking this medicine

  • Women with chance of becoming pregnant and men whose partner have a possibility of pregnancy should avoid pregnancy while you are taking this medicine and for a certain period of time after you discontinue this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include taste abnormality, nausea, decreased appetite, fever, vomiting, anemia, and fatigue. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemic symptoms, fever. bleeding tendency [myelosuppression]
  • cold-like symptoms, body dullness, fever [infection]
  • chest pain, palpitation, chest discomfort [QT-interval prolongation]
  • decreased consciousness, decreased urine output, shortness of breath [tumor lysis syndrome]
  • respiratory distress, hypotension [hypersensitivity]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.