くすりのしおり

Internal
Revised: 7/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
LenaDex Tablets 4mg
 Active ingredient:
Dexamethasone
 Dosage form:
white to grayish white tablet with a split line on one side, diameter: 9.1 mm, thickness: 2.5 mm
 Print on wrapping:
(face) LenaDex4mg, レナデックス4mg, (back) レナデックス4mg

Effects of this medicine

This medicine reduces myeloma cells and prevents proliferation of myeloma cells by inducing destruction of myeloma cells (apoptosis) or other actions.
It is usually used to treat multiple myeloma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have infections, systemic mycosis, peptic ulcer, mental disease, tuberculosis, herpes simplex keratitis, cataract, glaucoma, hypertension, thrombosis, history of acute myocardial infarction, poor controlled diabetes.
    If you are prone to swelling.
    If you have recently received surgery of internal organ.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 10 tablets (40 mg of the active ingredient) at a time, once a day for 4 days. The dosage may be decreased according to your symptoms and other antineoplastic medicine(s) to be concurrently used. Strictly follow the instructions.
  • If you miss a dose, you should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Pay close attention not to be affected with varicella or measles, as it may lead to a serious state.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include insomnia, impotent feeling, fatigue, paresthesia and muscle spasm. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, sore throat, cough [induced infection, exacerbation of infection]
  • general malaise, loss of appetite, dry mouth [secondary adrenocortical insufficiency, diabetes]
  • lower back pain, pain in the hip joint when standing up or walking, muscular stiffness [osteoporosis, aseptic necrosis (thigh/upper arm bone, etc.), myopathy, vertebral compression fracture, pathological fracture of long bone]
  • pain/tenderness in the pit of the stomach, heartburn, vomiting [peptic ulcer, gastrointestinal perforation, pancreatitis]
  • severe eye pain, reduced visual acuity, sensitive to bright light [glaucoma, posterior subcapsular cataract]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • After splitting the tablet, store away from light and use within one month.
  • Discard the remainder. Do not store them.
  • When you receive a vaccination of live vaccine, consult with your doctor.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.