くすりのしおり

Internal
Published: 4/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ALUNBRIG Tablets 90mg
 Active ingredient:
Brigatinib
 Dosage form:
white to eggshell white oval tablet, major axis: approx. 14.8 mm, minor axis: approx. 6.7 mm, thickness: approx. 5.1 mm
 Print on wrapping:
(Face)アルンブリグ錠90mg, お薬を飲み終わるまでアルミシートは出さないでください, (Back)アルンブリグ錠90mg, ALUNBRIG Tablets 90mg

Effects of this medicine

This medicine suppresses cancer cell growth by inhibiting ALK fusion protein tyrosine kinase essential for cancer cell growth.
It is usually used to treat unresectable advanced/recurrent non-small cell lung cancer positive for ALK fusion gene.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: interstitial lung disease or its history, renal dysfunction or liver dysfunction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablets (90 mg of brigatinib) at a time, once a day for 7 days, and then take 2 tablets (180 mg) at a time, once a day. The dosage may be decreased according to the conditions. Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and follow your regular dosing schedule on the following day. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • If you or your partner have a possibility of pregnancy, avoid pregnancy while you are taking this medicine and for a certain period of time after you discontinue this medicine.
  • Refrain from taking grapefruit juice or any food containing St. John's wort (a kind of herb) with this medicine, because the effect of this medicine may be affected.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include cough, hypertension, diarrhea, nausea. stomatitis, vomiting, constipation, loss of appetite, abdominal pain, muscle pain, rash, photosensitivity, itch and fatigue. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • shortness of breath, dyspnea, cough, fever [interstitial lung disease]
  • severe pain in the upper abdomen/lower back, fever, nausea/vomiting, loss of appetite [pancreatitis]
  • general malaise, loss of appetite, nausea/vomiting [liver dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.