Effects of this medicine
This medicine suppresses function of TNF (tumor necrosis factor) α, which is one of the possible primary causative substances in juvenile idiopathic arthritis. TNF is one of the cytokines existing inside of the body even in a healthy state, and involved in activities of immunity and development of inflammation or pain.
It is usually used to treat active polyarticular-course juvenile idiopathic arthritis with inadequate response to conventional therapies.
Dosing schedule (How to take this medicine)
- Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))
- In general, for patients with body weight of 15 kg to less than 30 kg, inject 20 mg of the active ingredient subcutaneously, once every two weeks. For patients with body weight of more than 30 kg, inject 40 mg of the active ingredient subcutaneously, once every two weeks. This preparation contains 20 mg of the active ingredient in a syringe. Strictly follow the instructions.
- Inject this medicine to the thighs, abdomen or upper arms. Injection site should be rotated and changed every time you inject this medicine. Do not inject this medicine to sensitive area of skin, wound site, rash or a cutaneous lesion. Do not massage the subcutaneous injection site.
- Inject this medicine to the area at least 3 cm apart from the previously injected site.
- Please use the whole amount at one time.
- If you miss an injection, contact your doctor. You should never inject two doses at one time.
- If you accidentally inject more than your prescribed dose, consult with your doctor or pharmacist.
- Do not stop injecting this medicine unless your doctor instructs you to do so.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include upper respiratory tract infection (such as nasopharyngitis), injection site reaction (erythema, itch, rash, bleeding, swelling) and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- chills, sudden high fever with shivering, cough/phlegm [serious infections]
- prolonged slight fever/cough (2 weeks or longer), general malaise, weight loss [tuberculosis]
- joint pain, muscle pain, skin eruption [lupus-like syndrome]
- reduced visual acuity/double vision, numbness/pain/motor paralysis [demyelinating disease]
- respiratory distress, hives, swelling around the eyes or lips [serious allergic reaction]
- general dullness, fever, prolonged bleeding, bleeding tendency, nose bleeding, blue spot, shortness of breath [serious blood disorder]
- fever, dry cough, breathing difficulty, shortness of breath [interstitial pneumonia]
- malaise, loss of appetite, yellowing of the skin and the white of eyes [fulminant hepatitis, liver dysfunction, jaundice, liver failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.