くすりのしおり

Internal
Published: 12/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
PREGABALIN OD Tablets 25 mg "KMP"
 Active ingredient:
Pregabalin
 Dosage form:
white tablet, diameter: 6.5 mm, thickness: 3.4 mm
 Print on wrapping:
プレガバリンOD錠25mg「KMP」, プレガバリン, OD, 25, Pregabalin OD 25mg「KMP」, プレガバリンOD「KMP」

Effects of this medicine

This medicine inhibits calcium influx by binding to Ca channels in the central nervous system and blocks neurotransmission by suppressing the release of excitatory neurotransmitters such as glutamic acid, soothes excessive excitement of nerve cells and relieve pain.
It is usually used to treat neuropathic pain and pain associated with fibromyalgia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: renal dysfunction or congestive heart failure.
    If you have a history of angioedema.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Neuropathic pain: In general, for adults, as an initial dose, take 3 tablets (75 mg of the active ingredient) at a time, twice a day, and then the daily dosage may be gradually increased up to 12 tablets (300 mg) in a week or more. The dosage may be adjusted according to the age or symptoms. However, the maximum daily dosage is 24 tablets (600 mg) in two divided doses.
    Pain associated with fibromyalgia: In general, for adults, as an initial dose, take 3 tablets (75 mg of the active ingredient) at a time, twice a day. The daily dosage may be gradually increased up to 12 tablets (300 mg) in a week or more and will be maintained at 12 to 18 tablets (300 to 450 mg). The dosage may be adjusted according to the age or symptoms. However, the maximum daily dosage is 18 tablets (450 mg) in two divided doses.
    In any case, strictly follow the instructions.
  • This medicine can be taken with saliva only. Crush the tablet lightly with your tongue and swallow it with saliva.
  • If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause dizziness, somnolence or loss of consciousness. Do not operate dangerous machinery such as driving a car. Especially, if you are an elderly adult, pay close attention because there is a case resulted in falling and fracture due to these symptoms.
  • Be aware of alcohol, since it may intensify the therapeutic effects of this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include dizziness and edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • dizziness, state close to sleep with impaired consciousness, loss of consciousness [dizziness, somnolence, unconsciousness]
  • breathing difficulty, general edema, palpitations on exertion [heart failure, pulmonary edema]
  • muscle pain of limbs, lassitude, reddish brown urine [rhabdomyolysis]
  • decreased urine output, edema, headache [renal failure]
  • swollen eyelid, lip and tongue, hives, respiratory distress [angioedema]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.