くすりのしおり

External
Revised: 8/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
RIVASTACH Patches 9mg
 Active ingredient:
Rivastigmine
 Dosage form:
round flat transdermal patch with beige-colored backing layer, size: 5 square centimeter
 Print on wrapping:
9mg, リバスタッチ

Effects of this medicine

This medicine increases brain acetylcholine level by inhibiting actions of degrading enzyme of acetylcholine which is a neurotransmitter in the brain, and facilitates neuro transmission. It consequently delays the progression of dementia symptoms such as memory impairment (forgetfulness), disorientation (problems in cognition of time and place) and difficulty in making judgments. It is usually used to suppress the progression of Alzheimer type dementia symptoms.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have cardiac disorder such as sick sinus syndrome, sinoatrial block, atrioventricular block, myocardial infarction, valvular disease or cardiac myopathy, or electrolyte abnormality (e.g. hypokalemia), gastric ulcer, duodenal ulcer, urinary tract obstruction, convulsive disease such as epilepsy, bronchial asthma, obstructive pulmonary disease, Parkinson disease, Parkinson syndrome or hepatic dysfunction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start at 4.5 mg patch, once a day, then the dose will be increased by 4.5 mg at 4 week intervals in principle. Eventually, apply a 18 mg patch once a day as a maintenance dose. Depending on your condition, you could start at 9 mg patch once a day, then the dose may be increased to 18 mg patch after 4 weeks in principle. Apply only one patch a day on intact healthy skin either on the back, upper arm or chest, and replace it with a new one every 24 hours. Strictly follow the instructions.
  • Apply only one patch at a time. Do not apply more than one patch at a time.
  • When replacing the patch, remove the old patch and then apply a new one.
  • The application site should be changed every time you replace the patch.
  • Avoid applying the patch on areas with wound or skin lesion.
  • Apply on clean and dry skin with little hair. Application site should be resistant to rubbing by tight clothing.
  • When applying after taking bath, remove moisture and dry the area before applying.
  • The patch should be replaced with a new one every day.
  • Press the patch firmly with your palm until it sticks firmly to the application area.
  • If the patch falls of, replace with a new one, and continue your regular applying schedule from the next day.
  • Do not cut the patch.
  • Wash your hands and do not touch the eye with your hand after applying the medicine.
  • You should use the patch under observation of healthcare workers or caregivers.
  • If you miss a dose, apply a dose as soon as possible and then continue your regular applying schedule instructed from your doctor. You should never apply two doses at one time.
  • If you accidentally apply more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop applying this patch unless your doctor instructs you to do so.

Precautions while taking this medicine

  • The medicine may cause dizziness and drowsiness. Avoid driving a car or operating dangerous machinery.
  • Pay attention to change in your body weight since the medicine may cause decreased weight.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include erythema (rash, redness), itch, dermatitis, swelling, nausea, vomiting and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • chest pain, cold sweat, dizziness [angina pectoris, myocardial infarction, bradycardia, atrioventricular block, sick sinus syndrome]
  • headache, vomiting, sudden muscle rigidity and body stiffness [cerebrovascular accident, convulsive seizure]
  • vomiting, epigastric pain, black stool [severe vomiting with esophageal rupture, gastric ulcer, duodenal ulcer, gastrointestinal bleeding]
  • loss of appetite, general malaise, nausea [hepatitis]
  • loss of consciousness [syncope]
  • seeing or hearing things that do not exist, extremely overwrought emotion or voice, mild disturbance of consciousness with illusion or hallucination [hallucination, agitation, delirium, confusion]
  • overbreathing, disturbance of consciousness, trembling of fingers [dehydration]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the used patches folding the adhesive surface inwards, and keep out of the reach of children.
  • Discard the remainder. Do not store them. Ask the pharmacy or medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.