くすりのしおり

Internal
Revised: 5/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
EquMet Combination Tablets LD
 Active ingredient:
Vildagliptin
Metformin Hydrochloride
 Dosage form:
pale yellow oval tablet, major axis: 14.2 mm, minor axis: 5.7 mm, thickness: 5.0 mm
 Print on wrapping:
(face) エクメット 配合錠 LD, 糖尿病用薬
(back) EquMet LD, エクメット 配合錠, LD, 糖尿病用薬, NVR, CCC

Effects of this medicine

This medicine inhibits the enzyme which degrades incretin, a hormone adjusting blood glucose levels, and promotes insulin secretion according to blood glucose levels. This medicine also suppresses production of glucose in the liver and promotes the use of glucose in the muscles, resulting in better blood sugar control.
It is usually used to treat type 2 diabetes mellitus.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itches, rashes, etc.) to any medicines.
    If you have a medical history of lactic acidosis.
    If you have renal/cardiovascular/lung/liver/pituitary gland/adrenal dysfunction, dehydration, gastrointestinal disorder, difficulty in oral intake, diabetic ketoacidosis, diabetic coma or precoma, type 1 diabetes mellitus, infection or injury.
    If you are prone to hypoxemia, on dialysis, in the pre-/post-operative period, malnourished, starved or debilitated.
    If you have had excessive alcohol consumption.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, twice a day (morning and evening). Strictly follow the instructions.
  • If you miss a dose, take a dose soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow diet and exercise therapy instructed by your doctor.
  • Please note that dehydration or excessive alcohol intake is likely to increase the risk of lactic acidosis.
  • This medicine may cause hypoglycemia. Pay attention when working at heights, driving a car or operating dangerous machinery.
  • If you noticed any symptoms of hypoglycemia, take sufficient amounts of sugar (sugar, glucose, soft drinks, etc.). If you are taking the medicine concomitantly with an alfa-glucosidase inhibitors (medicines which delay absorption of sugar), ingest glucose in case of any hypoglycemic symptoms.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include constipation, diarrhea and nausea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • gastrointestinal symptoms such as nausea/vomiting, malaise, muscle pain [lactic acidosis]
  • general malaise, yellow discoloration of skin and/or conjunctiva, loss of appetite [hepatitis, liver disorder, jaundice]
  • swelling of eyelids/lips/tongue, difficulty breathing, hives [angioedema]
  • a sense of hunger, weakness, cold sweat [hypoglycemia]
  • muscle pain, weakness, reddish brown urine [rhabdomyolysis]
  • persistent severe abdominal pain, back pain, vomiting [acute pancreatitis]
  • abdominal bloating, abdominal pain, vomiting [intestinal obstruction]
  • dry cough, breathing difficulty, fever [interstitial pneumonia]
  • intensely itchy blisters [pemphigoid]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remaining medicine. Do not store. Ask your pharmacy or medical institution on how to discard the remainder.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.