くすりのしおり

Internal
Published: 7/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
GLUBES Combination OD Tab.
 Active ingredient:
Mitiglinide calcium hydrate
Voglibose
 Dosage form:
pale reddish white tablet, diameter: 8.0 mm, thickness 3.9 mm
 Print on wrapping:
グルベス配合OD錠 糖尿病用薬 食直前に服用 GLUBESOD 口腔内崩壊錠 GBOD

Effects of this medicine

This medicine stimulates insulin secretion, and by blocking the enzyme α-glucosidase that degrades carbohydrates to glucose, it delays glucose absorption from the small intestine which enables to control the elevation of blood-glucose level after meal (postprandial hyperglycemia) and improves glycemic control.
It is usually used to treat type 2 diabetes.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you are a patient with ketosis, diabetic coma or precoma, type 1 diabetes, infection, hepatic or renal dysfunction, heart disease, undergone a laparotomy, experienced bowel obstruction, Roemheld syndrome, intestinal disorder, pituitary gland malfunction, adrenal gland dysfunction or gastrointestinal disorder.
    If you are in pre/postoperative period.
    If you are injured, starving, state of malnutrition or debility, or an alcohol consumer.
    If you engage in intense muscular exercise.
  • If you are pregnant, possibley pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, 3 times a day, just before (within 5 minutes) meals. Strictly follow the instructions of your doctor/pharmacist.
  • This medicine is orally disintegrating tablet. Moisten the tablet with saliva on your tongue and swallow with saliva. You can also take this medicine with water as you do an ordinary tablet.
    However, never take the tablet without water when you are in a lying position.
  • If you miss a dose, and have already started a meal, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than prescribed), check with your doctor/pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow the diet and exercise therapy instructed by your doctor.
  • The medicine may cause you to have hypoglycemic symptoms such as dizziness or light-headedness. Pay close attention when you drive, work at heights, or operate dangerous machinery while taking it.
  • If you have hypoglycemic symptoms, take glucose not sucrose or something containing enough glucose such as soft drink.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include symptoms of hypoglycemia, enlarged feeling of abdomen, numbness, abdominal pain, increased flatus, weight increase and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • pressured feeling or constrictive pain in chest, cold sweat  [myocardial infarction]
  • dizziness, abnormal craving for food, tremor in limbs  [hypoglycemia]
  • abdominal distension, meteorism, increased flatus [bowel obstruction]
  • general malaise, loss of appetite, yellowing of the skin and the white of eyes [fulminant hepatitis, hepatic dysfunction, jaundice ]
  • constipation, faint consciousness, judgment failure [disturbance of consciousness due to exacerbation of heperammonemia in patients with liver cirrhosis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from direct sunlight heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.