くすりのしおり

Internal
Published: 6/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Gefitinib Tablets 250mg "Nichiiko"
 Active ingredient:
Gefitinib
 Dosage form:
brown round tablet, diameter: 11.1 mm, thickness: 5.5 mm
 Print on wrapping:
ゲフィチニブ錠250mg「日医工」,ゲフィチニブ,250mg,日医工,n211,Gefitinib Tab.250mg,「日医工」

Effects of this medicine

This medicine selectively inhibits epidermal growth factor receptor (EGFR) thyrosin kinase to show the effect to suppress cancer cell proliferation.
It is usually used to treat EGFR mutation positive inoperable or recurrent non-small cell lung cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have acute lung disorder, idiopathic pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-induced pneumonia or history of any of them.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet (250 mg of the active ingredient) at a time, once a day. Strictly follow the instructions.
  • In elderly patients, take this medicine after the meal if possible, as gastric acid secretion may decrease.
  • If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause weakness. Pay close attention to operate in potentially hazardous activities such as driving a car.
  • Do not intake foods containing St. John's wort as it may weaken the effect of this medicine.
  • Do not take grapefruit juice and the medicine together as the components of it may intensify the effect of this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include skin symptoms such as rash, itch, dry skin, skin fissure or acne and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, dry cough, fever [acute lung disorder, interstitial pneumonia]
  • muddy or liquidy stool [severe diarrhea]
  • diarrhea, nausea/vomiting, loss of appetite [dehydration]
  • high fever, bloodshot eyes, erythema [toxic epidermal necrolysis, mucocutaneous-ocular syndrome, erythema multiforme]
  • general malaise, loss of appetite, yellowing of the skin and the white of eyes [hepatitis, liver dysfunction, jaundice, liver failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist or medical facility how to discard unneeded medicine.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.