Dosing schedule (How to take this medicine)
- Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))
- Classical Hodgkin's lymphoma, head and neck cancer, gastric cancer, malignant pleural mesothelioma, esophageal cancer: In general, for adults, administer by intravenous infusion once every 2 weeks or once every 4 weeks.
Malignant melanoma, renal cell carcinoma, colorectal cancer: In general, for adults, administer by intravenous infusion once every 2 weeks or once every 4 weeks. However, in the case of the adjuvant therapy in the malignant melanoma, the treatment duration is up to 12 months. In general, for adults, administer by intravenous infusion in combination with ipilimumab 4 times every 3 weeks, then followed by intravenous infusion once every 2 weeks or once every 4 weeks.
Non-small cell lung cancer: In general, for adults, administer by intravenous infusion once every 2 weeks or once every 4 weeks. In general, for adults, administer by intravenous infusion in combination with other anticancer agents once every 2 weeks or once every 3 weeks.
- In general, administer by intravenous infusion for at least 30 minutes at a time.
- Ask your doctor about your dosing schedule.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include fatigue, itch, nausea, decreased appetite, rash, diarrhea, fever, hypothyroidism, arthralgia, asthenia, vitiligo, malaise, vomiting, liver dysfunction, muscle pain, infusion reaction, and anemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- fever, dry cough, respiratory distress [interstitial pulmonary disease]
- muscle weakness, droopy eyelid, respiratory distress, swallowing disorder, muscle pain, palpitation, chest pain [myasthenia gravis, myocarditis, myositis, rhabdomyolysis]
- persistent diarrhea, abdominal pain, bloody stool [colitis, enteritis, severe diarrhea]
- dry mouth, nausea, vomiting, general malaise, polyuria [type 1 diabetes]
- general malaise, bleeding tendency, anemia, fever, sore throat [serious blood disorder]
- general malaise, loss of appetite, yellowing of the skin and the white of eyes, upper abdominal pain, pain particularly in the upper right abdomen, itch, bleeding tendency, consciousness disorder [fulminant hepatitis, liver failure, liver dysfunction, hepatitis, sclerosing cholangitis]
- general malaise, edema, sweating, decreased body weight [disturbed thyroid function]
- general malaise, decreased consciousness, blood pressure drop [pituitary dysfunction]
- paralysis, paralysis of the lower part of the body, numbness of limbs, pain in limbs [nervous disorder]
- decreased urine output, facial edema, swelling in the eyelid, headache [renal disorder]
- general malaise, decreased consciousness, vomiting, loss of appetite, hypotension [adrenal disorder]
- fever, headache, vomiting [encephalitis]
- generalized red spot and breakable blister, red rash, red spot with swelling in the center, fever [severe skin disorder]
- edema, feeling hot, local pain [venous thromboembolism]
- respiratory distress, consciousness disorder, swelling of eyelids/lips/tongue, fever [infusion reaction]
- fever, pressured feeling and pain in the left upper abdomen, lymph node swelling [hemophagocytic syndrome]
- night sweat, weight loss, general malaise, slight fever, prolonged cough [tuberculosis]
- severe pain in the upper abdomen, back pain, fever, nausea, vomiting, loss of appetite [pancreatitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.