くすりのしおり

Internal
Revised: 11/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Revolade Tablets 25mg [chronic idiopathic thrombocytopenia purpura]
 Active ingredient:
Eltrombopag olamine
 Dosage form:
white tablet, diameter: 10.3 mm, thickness: 4.2 mm
 Print on wrapping:
(front) レボレード25 mg, (back) REVOLADE25 mg, レボレード25 mg, GSNX3 25

Effects of this medicine

This medicine acts on thrombopoietin receptors which are involved in production of platelets and consequently increases platelets.
It is usually used in the treatment of chronic idiopathic thrombocytopenic purpura.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you have hepatic disorder or renal disorder.
  • If you are prone to thromboembolism.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 12.5 mg of eltrombopag at a time, once daily, on an empty stomach as an initial dose. Avoid taking the medicine within 2 hours before and after meals. The dosage may be adjusted according to the platelet counts or symptoms, however, the maximum daily dose is limited to 2 tablets (50 mg).
    This preparation contains 25 mg of eltrombopag in a tablet. Strictly follow the instructions.
  • If you miss a dose, do not take the medicine on the day and take your next scheduled dose. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Taking the medicine with a meal may reduce the therapeutic effects of the medicine. Avoid taking the medicine within 2 hours before and after meals.
  • Taking the medicine with dairy products or supplements containing minerals (iron, calcium, aluminum, magnesium, selenium, zinc, etc.) may diminish the therapeutic effects of the medicine. Avoid taking dairy products or these supplements within 4 hours before and 2 hours after taking the medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include fatigue, cataract, chest pain, headache, nausea and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general malaise, loss of appetite, nausea [hepatic dysfunction]
  • local pain, edema, consciousness disorder, dyspnea, hemiplegia of limbs, numbness [thromboembolism]
  • nasal bleeding, gum bleeding, subcutaneous bleeding [bleeding]
  • palpitation, symptoms of anemia, fever [bone marrow fibrosis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.