Dosing schedule (How to take this medicine)
- Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))
- Radically unresectable malignant melanoma: In general, for adults, inject intravenously at an interval of once every 3 weeks for a total of 4 doses for 90 minutes at a time. It may be administered in combination with nivolumab.
Unresectable or metastatic renal cell carcinoma, microsatelite instability high (MSI-High) colorectal advanced / recurrental cancer progressing after cancer chemotherapy: In general, for adults, in combination with nivolumab, inject intravenously at an interval of once every 3 weeks for a total of 4 doses for 30 minutes at a time.
Unresectable advanced / recurrent non-small cell lung cancer: In general, for adults, in combination with other anticancer agents, including nivolumab, inject intravenously at an interval of once every 6 weeks for 30 minutes at a time.
Unresectable advanced / recurrent malignant pleural mesothelioma: In general, for adults, in combination with nivolumab, inject intravenously at an interval of once every 6 weeks for 30 minutes at a time.
Ask your doctor about your dosing schedule.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, fever, itching, decreased appetite, diarrhea, hypothyroidism, malaise, liver dysfunction, vomit, constipation, fatigue, arthralgia, colitis, respiratory distress, headache, maculopapular rash, nausea and stomatitis, asthenia, hyperthyroidism (sweating, body weight loss, tachycardia). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, see your doctor immediately.
- diarrhea, abdominal pain, bloody stool [colitis, perforation of the digestive tract, severe diarrhea]
- general malaise, loss of appetite, jaundice [liver failure, liver dysfunction]
- rash, skin itching, pain [severe skin disorder]
- headache, general malaise, defect in the visual field [hypophysitis, hypopituitarism, hypothyroidism, adrenal gland dysfunction]
- numbness in limbs, pain, inactive sensory, movement disorder [peripheral neuropathy]
- decreased urine output, facial edema, swelling in the eyelid, headache [renal disorder]
- fever, dry cough, respiratory distress [interstitial pulmonary disease]
- muscle weakness, muscle pain, fever [myositis]
- labored breathing, shortness of breath, palpitation, fever, nausea, vomiting, general malaise [myocarditis]
- chill, dizziness, respiratory distress [infusion reaction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.