くすりのしおり

Internal
Revised: 1/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
JAKAVI Tablets 5mg[myelofibrosis]
 Active ingredient:
Ruxolitinib Phosphate
 Dosage form:
white tablet, diameter: 7.5 mm, thickness: 3.6 mm
 Print on wrapping:
ジャカビ5mg, JAKAVI5mg, NVR L5

Effects of this medicine

This medicine reduces the size of enlarged spleen (splenomegaly) due to myelofibrosis by selectively blocking the action of certain enzymes (Janus Kinases) involved in myelofibrosis.
It is usually used to treat myelofibrosis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have any infections or hepatitis.
    If you have ever had tuberculosis or hepatitis.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 5 to 25 mg of ruxolitinib at a time, twice a day, about every 12 hours as a guide. The dosage may be adjusted according to your symptoms. This medicine contains 5 mg of ruxolitinib in a tablet. Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and take your next dose at the schedule time. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may increase susceptibility to infection. Wash your hands and gargle frequently, and maintain hygiene.
  • Avoid taking hypericum perforatum (Saint John's wort)-contained supplements, etc., since it may weaken the therapeutic effects of this medicine.
  • If you have a possibility of pregnancy, avoid pregnancy to use highly effective contraception during taking this medicine and for a certain period after completion of this medication, since fetal toxicity was reported in an animal study.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, fatigue and weight gain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemia symptoms, fever, bleeding tendency [myelosuppression]
  • cold-like symptoms (chills, fever), malaise, vomiting [infection]
  • impaired consciousness/memory disorder/speech difficulties, light headedness, convulsion [progressive multifocal leukoencephalopathy: PML]
  • general malaise, loss of appetite, nausea [abnormal liver function]
  • fever, dry cough, breathing difficulty [interstitial lung disease]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist or the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.