くすりのしおり

Injection
Revised: 1/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Zoledronic Acid I.V. Drip Infusion 4mg/100mL Bag "Nichiiko"[bone lesion]
 Active ingredient:
Zoledronic acid hydrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine relieves bone pain caused by multiple myeloma and bone metastasis of cancer and prevents bone fracture.
It is usually used to treat bone lesion caused by multiple myeloma and bone metasis of solid cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject by intravenous infusion once every 3 to 4 weeks.
  • The frequency of injection may be decided depending on your symptoms.

Precautions while taking this medicine

  • You may be instructed by your doctor to take calcium and vitamin D as necessary.
  • Maintain your oral hygiene while using this medicine.
  • Inform your dentist or oral surgeon that you are using this medicine when you receive the dental treatment such as extraction.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include erythematous rash, macular rash, angioneurotic edema, hives, erythema, blister, rash, eczema and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • decreased urine output, edema of limbs and face, fever [acute renal failure, interstitial nephritis, fanconi syndrome]
  • respiratory distress, fatigueness, edema of lower limbs [congestive heart failure (edema, respiratory distress, pulmonary edema)]
  • convulsion, lassitude in muscle, numbness [hypocalcemia]
  • cough, respiratory distress, fever [interstitial pneumonia]
  • pain/swelling of jaw, numbness of jaw, loose teeth [osteonecrosis and osteomyelitis of the jaw]
  • ear pain, ear discharge [osteonecrosis of the external auditory canal]
  • pain of the thigh/inguinal region [atypical subtrochanteric and proximal femoral fracture]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.