Search results detail| Kusurino-Shiori(Drug information Sheet)

Nichi-iko Pharmaceutical Co.,Ltd

Injection
Revised: 6/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

Brand name :

Levofolinate I.V. Drip Infusion 100mg "Nichiiko"

　Active ingredient:

Calcium levofolinate hydrate

　Dosage form:

injection

　Print on wrapping:

Effects of this medicine

This medicine enhances effect to suppress cancer cell proliferation by concomitant with fluorouracil (anti-tumor medicine).
It is usually used to enhance effect of fluorouracil in gastric cancer (inoperable/recurrence) , small intestinal/colon/rectal cancer and incurable/unresectable pancreatic cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have myelosuppression, diarrhea, varicella, other infection, peritoneal/pleural effusion, heart disease or poor general condition.
If you have a history of heart disease.
If you have stopped using tegafur/gimeracil/oteracil potassium combination ingredient within 7 days.

If you are pregnant or breastfeeding.

If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))

In general, for adults, inject by intravenous infusion at a time for 2 hours.
The interval of injection may be decided according to concomitant medicines, symptoms and condition of the patient. Ask the doctor for the detailed schedule.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include loss of appetite, nausea/vomiting, taste abnormality, abdominal pain, pain around pit of stomach, thirst, constipation, gingivitis, cheilitis/angular stomatitis, glossitis, bloating, melena, heart burn and rash. If any of these symptoms occur, consult with your doctor or pharmacist.

The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

muddy or watery stool [severe diarrhea]
abdominal pain, diarrhea, nausea [severe enteritis]
anemic symptoms, fever, bleeding tendency [myelosuppression]
rash, respiratory distress, decreased blood pressure [shock, anaphylaxis]
light headedness in walking, numbness in terminal limbs, language disorder [leukoencephalopathy, psychiatric/neurological disorder]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.