くすりのしおり

Injection
Revised: 6/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Irinotecan Hydrochloride I.V. Drip Infusion 40mg "Nichiiko"
 Active ingredient:
Irinotecan hydrochloride hydrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine inhibits DNA synthesis of cancer cells to suppress proliferation of cancer cell.
It is usually used to treat small cell lung cancer, non-small-cell lung cancer, cervical cancer, ovarian cancer, gastric cancer(inoperable or recurrence), colon/rectal cancer (inoperable or recurrence), breast cancer (inoperable or recurrence), squamous cell carcinoma, malignant lymphoma (non-Hodgkin's lymphoma), malignant solid tumor of childhood, incurable/unresectable pancreatic cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have myelosuppression, infection, diarrhea (watery stool), intestinal paralysis, ileus, interstitial pneumonitis, pulmonary fibrosis, ascitic/pleural fluid or jaundice.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject by intravenous infusion once a day.
  • The interval of injection may be decided according to concomitant drugs and symptoms of the patient. Ask the doctor for the detailed schedule.

Precautions while taking this medicine

  • Do not drink grapefruit juice during treatment as the components of it may intensify the effect of this medicine. And do not intake foods containing St. John's wort during treatment as it may weaken the effect of this medicine.
  • If you have decreased bone-marrow function, infection or bleeding may occur. These symptoms are difficult to detect. In order to find out symptoms as early as possible, periodic blood test is needed (once to twice a week, or more frequently in some cases).

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea/vomiting, loss of appetite, abdominal pain and hair loss. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemia symptoms, fever, bleeding tendency [myelosuppression]
  • muddy or watery stool, abdominal pain, diarrhea [severe diarrhea, enteritis]
  • severe abdominal pain, abdominal pain, obstruction of intestinal content [intestinal perforation, gastrointestinal bleeding, ileus]
  • fever, cough, respiratory distress [interstitial pneumonia]
  • respiratory distress, decreased blood pressure, pale face [shock, anaphylaxis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.