くすりのしおり

Internal
Revised: 4/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Zovirax Tablets 400
 Active ingredient:
Aciclovir
 Dosage form:
white tablet, diameter: 11 mm, thickness: 5.2 mm
 Print on wrapping:
(face) ゾビラックス 400mg, ゾビラックス400, 400 (back) GSK, Zovirax 400mg, ゾビラックス 400mg, GX CM1, 抗ウイルス薬

Effects of this medicine

This medicine suppresses the increase of viruses by inhibiting virus DNA replication.
It is usually used to treat herpes simplex, herpes zoster, and as a suppression of onset of herpes simplex virus infection associated with hematopoietic stem cell transplantation and recurrence of genital herpes (in children who weigh more than 40 kg only).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: renal or liver disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • [Adults]
    Herpes simplex: In general, for adults, take 1/2 tablet (200 mg of the active ingredient) at a time, 5 times a day.
    Suppression of onset of herpes simplex virus infection (herpes simplex) associated with hematopoietic stem cell transplantation: In general, for adults, take 1/2 tablet (200 mg of the active ingredient) at a time, 5 times a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation.
    Herpes zoster: In general, for adults, take 2 tablets (800 mg of the active ingredient) at a time, 5 times a day.
    [Children]
    Herpes simplex: In general, for children, take 20 mg of the active ingredient per kilogram of the body weight at a time, 4 times a day. The maximum single dose is 1/2 tablet (200 mg of the active ingredient).
    Suppression of onset of herpes simplex virus infection (herpes simplex) associated with hematopoietic stem cell transplantation: In general, for children, take 20 mg of the active ingredient per kilogram of the body weight at a time, 4 times a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation. The maximum single dose is 1/2 tablet (200 mg of the active ingredient).
    Herpes zoster: In general, for children, take 20 mg of the active ingredient per kilogram of the body weight at a time, 4 times a day. The maximum single dose is 2 tablets (800 mg of the active ingredient).
    Suppression of recurrence of genital herpes: In general, for children who weigh more than 40 kg, take 20 mg of the active ingredient per kilogram of the body weight at a time, 4 times a day. The maximum single dose is 1/2 tablet (200 mg of the active ingredient).
    In any case, the dosage may be adjusted according to the age or symptoms. Strictly follow the instructions.
  • In general, take the medicine 5 times a day (after breakfast, after lunch, at around 4 pm, after dinner and before bedtime).
    In general, for children, take the medicine 4 times a day (after breakfast, after lunch, at around 4 pm and after dinner).
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Please take a larger amount of water than usual while you are on this medicine. However, if you have been instructed to restrict fluid intake, please consult with your doctor or pharmacist.
  • This medicine may cause consciousness disorder. Pay close attention when driving a car or operating dangerous machinery. Patients with renal dysfunction are more susceptible to consciousness disorder, so avoid operating dangerous machinery if instructed to do so by your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include anemia, diarrhea, loose stool, nausea, vomiting, abdominal pain, gastric pain, epigastric pain, stomach discomfort, sleepiness and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, swelling of eyelids/lips/tongue, palpitation [anaphylactic shock, anaphylaxis]
  • fever, bleeding tendency, general malaise [blood disorder including pancytopenia/agranulocytosis]
  • decreased urine output, edema, general malaise [acute renal disorder, tubulointerstitial nephritis]
  • coma, hallucination, convulsion [neuropsychiatric symptom]
  • conjunctival hyperemia, erythema with edema on the center, erosions of oral or pubic mucosa [toxic epidermal necrolysis, oculomucocutaneous syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.