Dosing schedule (How to take this medicine)
- Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))
- Chronic myeloid leukemia: (chronic phase) In general, for adults, take 100 mg as dasatinib hydrate at a time once a day. The dosage may be adjusted according to the symptoms. The dose may be increased up to 140 mg at a time once a day. (accelerated phase/blast phase) In general, for adults, take 70 mg as dasatinib hydrate at a time twice a day. The dosage may be adjusted according to the symptoms. The dose may be increased up to 90 mg at a time twice a day.
Recurrent/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia: In general, for adults, take 70 mg as dasatinib hydrate at a time twice a day. The dosage may be adjusted according to the symptoms. The dose may be increased up to 90 mg at a time twice a day.
Each tablet contains 50 mg of dasatinib hydrate. Same medicine containing 20 mg of dasatinib hydrate may be used in combination. Strictly follow the instructions.
- If you missed a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
- If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
- Do not stop taking this medicine unless your doctor instructs you to do so.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include anemia, fever, rash, headache, diarrhea, malaise, edema, pleural effusion, cough, inflammation of nose and throat, constipation, nausea, body weight increased, muscle pain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- fever, chill, cough, nasal discharge, dizziness, bleeding tendency, continuous bleeding, bruise, dullness, easy fatigability, shortness of breath, sore throat [marrow depression]
- headache, consciousness disorder, abdominal pain [brain/subdural/gastrointestinal bleeding]
- breathing difficulty, dry cough, body weight increased [body fluid retention including pleural effusion/pulmonary edema/pericardial effusion/ascites/generalized edema]
- fever, malaise, chill [infection]
- fever, cough, dry cough, breathing difficulty [interstitial pneumonia]
- decreased urination [oncolytic syndrome]
- palpitation, faint [QT prolongation]
- palpitation, shortness of breath, chest pain, breathing difficulty [heart failure, myocardial infarction]
- inability to pass urine, urine with blood [acute renal failure]
- breathing difficulty on exertion, easy fatigability, dullness, faint, swollen legs [pulmonary hypertension]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.