くすりのしおり

Injection
Published: 5/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Remitoro Intravenous Drip Infusion 300mcg
 Active ingredient:
Denileukin diftitox (genetical recombination)
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine binds to an interleukin-2 (IL-2) receptor and shows tumor growth inhibitory effect by inhibiting protein synthesis, etc.
It is usually used for the treatment of the recurrent or refractory peripheral T-cell lymphoma and the recurrent or refractory cutaneous T-cell lymphoma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have myelosuppression.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, inject this medicine by intravenous infusion once a day over one hour for 5 days and then discontinue this medicine for 16 days. This dosing schedule is regarded as one course, which is repeated up to 8 courses. However, it may be varied according to adverse reactions, medicinal effects and patient's condition. Ask your doctor about the duration of administration.
  • You will be administered medicines to prevent allergic reactions and anaphylactoid symptoms before drip infusion of this medicine.

Precautions while taking this medicine

  • This medicine may cause visual impairment and achromatopsia. An ophthalmology examination is performed regularly before and during using this medicine. If you notice any abnormalities such as difficulty in seeing letters or shapes, abnormal visual field, foggy vision, difference in seeing/perceiving colors, or difficulty in understanding colors while using this medicine. Please consult your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include liver dysfunction, fever, malaise, nausea, constipation, and decreased appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • hypotension, systemic edema, sudden weight gain, shortness of breath, breathing difficulty [capillary leak syndrome]
  • limbs stiffness, numbness of limbs, lassitude, muscle pain, reddish brown urine [rhabdomyolysis]
  • difficulty in seeing letters or shapes, abnormal visual field, foggy vision, difference in seeing/perceiving colors, difficulty in understanding colors [visual impairment, achromatopsia]
  • general malaise, yellowing of the skin and the white of eyes, nausea [liver dysfunction]
  • general malaise and feverish more than usual, chills, sore throat, nasal bleeding, gum bleeding, bruise, prolonged bleeding [bone marrow suppression]
  • symptom such as a cold, malaise, fever, the part which it is hard to look at is in the view [pneumonia, cytomegalovirus chorioretinitis]
  • fever, chills, nausea, respiratory distress [infusion reaction (response with the infusion)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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