くすりのしおり

Internal
Published: 8/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Entresto Tablets 100 mg
 Active ingredient:
Sacubitril valsartan sodium hydrate
 Dosage form:
faint yellow oval tablet with split line, major axis: 13.1 mm, minor axis: 5.2 mm, thickness: 3.7 mm
 Print on wrapping:
エンレスト 100 mg, ENTRESTO 100 mg, L

Effects of this medicine

This medicine suppresses the actions of substances called neprilysin and angiotensin II to lower blood pressure, reduce the amount of water stored in the body, reduce the burden on the heart, and prevent worsening of heart failure.
It is usually used to treat chronic heart failure.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal artery stenosis, hyperkalemia, renal dysfunction, hepatic dysfunction, a history of angioedema, or schedule of surgery.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 50 mg of sacubitril valsartan at a time, twice a day as the initial dose. The dosage may be increased up to 200 mg at intervals of 2 to 4 weeks in a stepwise manner if the adverse reactions do not interfere with the treatment. The dose is 50 mg, 100 mg or 200 mg at a time. The dosage may be adjusted according to the tolerability. Each tablet of this medicine contains 100 mg of sacubitril valsartan. Strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause dizziness or lightheadedness. Pay close attention when you work at heights, drive a car or operate machinery.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hypotension and renal impairment. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • hoarse voice, difficulty speaking, difficulty swallowing  [angioedema]
  • general malaise, dizziness, lightheadedness  [hypotension]
  • numbness of limbs or lips, muscle weakness, paralysis of arm/legs  [hyperkalemia]
  • cold sweat, vomiting, loss of consciousness [shock]
  • decreased urine output, swelling of arm/legs, loss of appetite  [renal failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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