くすりのしおり

Internal
Published: 8/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
VAFSEO tablets 300mg
 Active ingredient:
Vadadustat
 Dosage form:
yellow oval tablet, major axis: approximately 12.9 mm, minor axis: approximately 7.8 mm, thickness: approximately 6.0 mm
 Print on wrapping:
(Face) バフセオ300mg, VAFSEO 300mg, VDT300
(Back) バフセオ300mg

Effects of this medicine

This medicine inhibits prolyl hydroxylase (PH) which is involved in the degradation of hypoxia inducible factor (HIF), and boosts erythropoietin which promotes red blood cell production. It consequently increases the production of hemoglobin and red blood cells, and improves anemia.
It is usually used to treat renal anemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itching, rash, etc.) to any medicines.
    If you have cerebral infarction, myocardial infarction, pulmonary embolism or its history.
    If you have hypertension.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with taking one tablet (300 mg of the active ingredient) at a time, once a day. Then the dosage may be adjusted according to the disease state. The dosage will be increased up to two tablets (600 mg of the active ingredient) once a day. Strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible. If it is close to your next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Blood and liver function tests may be performed periodically to measure hemoglobin levels and liver function levels. Keep all laboratory test schedules.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hypertension, diarrhea and nausea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • paralysis or numbness of limbs, difficulty speaking, localized pain or swelling, chest pain, dyspnea [thromboembolism]
  • general malaise, loss of appetite, nausea [hepatotoxicity]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. If you dispose of unused medicines, ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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