くすりのしおり

Internal
Revised: 10/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
CABPIRIN Combination Tablets
 Active ingredient:
Aspirin
Vonoprazan fumarate
 Dosage form:
white tablet, diameter: approx. 8.0 mm, thickness: approx. 3.9 mm
 Print on wrapping:
(Face)キャブピリン, 375 (Back)キャブピリン, アスピリン100mg, ボノプラザン10mg

Effects of this medicine

Aspirin inhibits activities of platelet cyclooxygenase-1 to suppress platelet aggregation and eventually delay or prevent blood coagulation while vonoprazan inhibits the proton pump in the gastric mucosa in a potassium ion-competitive manner to reduce gastric acid production.
Aspirin prevents obstruction of a blood vessel by a blood clot that has formed but may cause gastric/duodenal ulcers; therefore, vonoprazan prevents such untoward events.
It is usually used to suppress thrombus/embolus formation due to angina pectoris, myocardial infarction or ischemic cerebrovascular disorder or to suppress thrombus/embolus formation after coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) in patients with a history of gastric/duodenal ulcers.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have peptic ulcer, blood abnormality or a history of it, bleeding tendency or predisposition to it, bronchial asthma or a history of it, renal disorder or a history of it or liver disorder or a history of it.
    If you drink alcohol on a regular basis.
    If you are scheduled for surgery/cardiac catheter test/tooth extraction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, once a day. Strictly follow the instructions.
  • Swallow this medicine without cracking, crunching or grinding.
  • If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • If a long-term administration is performed, endoscopic examination is regularly conducted.
  • If you use this medicine for the treatment of cerebral infarction, try to maintain healthy blood pressure.
  • This medicine may induce or enhance gastrointestinal bleeding; therefore, avoid taking this medicine with any alcoholic beverage.
  • If you are scheduled for any treatment with bleeding, such as surgery, cardiac catheter test or tooth extraction while taking this medicine, consult with your doctor or pharmacist.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include constipation, diarrhea, abdominal bloating, nausea, abdominal pain, esophagitis, gastric distress, itch, anemia, decreased blood pressure and edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general malaise, fever, shortness of breath, nose bleeding/subcutaneous bleeding [pancytopenia, agranulocytosis, decreased white blood cell, decreased platelets, aplastic anemia]
  • fever, general malaise, rash of the skin/eyes/mouth, redness, skin falling off [toxic epidermal necrolysis, oculomucocutaneous syndrome, erythema multiforme, exfoliative dermatitis]
  • breathing difficulty, generalized rash [shock, anaphylaxis]
  • headache, nausea/vomiting, consciousness disorder, motor paralysis, phlegm with blood, melena, black stool, nose bleeding, vision disorder [bleeding]
  • breathing difficulty, whistling breath [asthmatic attack]
  • yellowing of the skin and the white of eyes, general malaise, loss of appetite [liver dysfunction, jaundice]
  • heartburn, stomach heavy feeling, abdominal pain, diarrhea, bloody stool [peptic ulcer, small/large intestine ulcer]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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