くすりのしおり

Injection
Published: 5/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ENHERTU FOR INTRAVENOUS DRIP INFUSION 100mg
 Active ingredient:
Trastuzumab Deruxtecan(Genetical Recombination)
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine suppresses growth of cancer cells by selectively entering cancer cells with HER2, which is required for growth of cancer cells, and inhibiting DNAs synthesis.
It is usually used to treat HER2-positive unresectable or recurrent breast cancer after prior chemotherapy (limit the use to patients who are refractory or intolerant to standard treatments).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have or have experienced interstitial lung disease.
    If you have or have previously experienced heart disease.
    If you have been previously treated with anthracycline medicines.
    If you are or were treated with radiation therapy.
    If you have or have been previously diagnosed with hypertension.
    If you have liver disease
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, administer by intravenous infusion once a day at an interval of once every three weeks.
  • Dosage and treatment period depend on the result from checking on the patient's conditions.

Precautions while taking this medicine

  • Since interstitial lung disease may occur, arterial oxygen saturation tests, chest X-ray scans and chest CT scans should be performed regularly. Keep all test schedules under the instruction of your doctor.
  • Since bone marrow depression may occur, blood test should be performed regularly. Keep blood test schedules under the instruction of your doctor.
  • If you or your partner have a possibility of pregnancy, avoid pregnancy while you are taking this medicine and for a certain period of time after you discontinue this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea, fatigue, alopecia, headache, anemia, diarrhea, constipation, stomatitis, and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • breathing difficulty, dry cough, fever [interstitial lung disease]
  • anemia, fever, bleeding tendency (nasal bleeding, gum bleeding, subcutaneous bleeding) [myelosuppression]
  • breathing difficulty, consciousness disturbance, swelling in the eyelids/lips/tongue, fever, chills, vomiting, cough, dizziness, palpitation [infusion reaction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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