くすりのしおり

Injection
Revised: 3/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DOXIL Injection 20mg
 Active ingredient:
Doxorubicin hydrochloride
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine shows suppressive effects on the proliferation of ovarian cancer cells and Kaposi's sarcoma cells.
It is usually used to treat ovarian cancer worsened after chemotherapy, and AIDS-related Kaposi's sarcoma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have or have previously experienced heart disease.
    If you have bone marrow suppression (fever, chills, dizziness, bleeding tendency, general malaise, fatigability and palpitation/shortness of breath), liver dysfunction or soybean allergy.
    If you have previously used anti-cancer medicines such as anthracycline.
    If you have previously received radiotherapy to the chest.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For ovarian cancer: In general, this medicine is injected intravenously slowly once a day. This medicine is used every 4 weeks.
    For AIDS-related Kaposi's sarcoma: In general, this medicine is injected intravenously slowly once a day. This medicine is used every 2 to 3 weeks.
  • The treatment span will depend on your response to treatment after this medicine is used for a certain period of time.

Precautions while taking this medicine

  • If you are taking medicines such as cyclophosphamide, receive heart examinations.
  • Because the color of this medicine is red, red discoloration of urine may occur.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hand and foot syndrome, stomatitis, nausea, loss of appetite, rash, fatigue, weight loss, asthenia, anemia, fever, alopecia, vomiting, diarrhea and oral moniliasis. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • palpitation/shortness of breath, chest pain, edema of legs [myocardial disorder]
  • fever, chills, bleeding tendency [bone marrow suppression]
  • hot flush, swelling of face, chills [infusion reaction]
  • swelling of limbs, redness of the skin, pain and rash of palmar and plantar [hand and foot syndrome]
  • fever, dry cough, respiratory distress [interstitial pneumonia]
  • respiratory distress, chest pain, consciousness disorder [pulmonary embolism]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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