くすりのしおり

Internal
Published: 3/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
AGRYLIN Capsules 0.5mg
 Active ingredient:
Anagrelide hydrochloride hydrate
 Dosage form:
white hard capsule, major axis: approx. 14.3 mm, minor axis: approx. 5.32 mm
 Print on wrapping:
(Face)アグリリン, 0.5mg, SO63, (Back)アグリリン, Agrylin 0.5mg

Effects of this medicine

This medicine selectively acts on "megakaryocyte", a cell producing platelets, to decrease platelets count.
It is usually used to treat essential thrombocythemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have liver dysfunction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start taking 1 capsule (0.5 mg of anagrelide) at a time, twice a day. The dosage may be adjusted according to the symptoms, but will be increased by 1 capsule (0.5 mg) per day, with an interval of at least one week, not exceeding 4 divided doses a day. However, the maximum single dose is 2.5 mg and maximum daily dose is 20 capsules (10 mg). Strictly follow the instructions.
  • You should not take two or more doses at one time.
  • If you miss a dose, skip the missed dose and strictly follow your regular dosing schedule. You should never take two or more doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. Decreased blood pressure, sinus tachycardia and vomiting have been reported. If you notice any abnormality, stop taking this medicine and consult with your doctor for appropriate treatment.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Receive medical examination on a regular basis to check the effects or adverse reactions of this medicine.
  • If you have bleeding tendency, pay attention not to get injured. If you need to undergo a surgery, tooth extraction, etc., consult with your doctor beforehand.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include anemia, headache, palpitation, diarrhea and edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • palpitation, general malaise, breathing difficulty [heart disorder]
  • palpitation, faint, chest pain [prolongation of QT interval, ventricular arrhythmia]
  • fever, dry cough [interstitial pneumonia]
  • nasal bleeding, gum bleeding, subcutaneous bleeding [bleeding]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.
  • Take a dose after taking it out of the PTP sheet.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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