くすりのしおり

Injection
Revised: 10/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
CATACLOT Injection 40mg [for use after surgery for subarachnoid hemorrhage]
 Active ingredient:
Ozagrel sodium
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine suppresses production of thromboxane A2 and promotes production of prostacyclin by selectively inhibiting thromboxane synthetase, leading to improvements in the imbalance between thromboxane A2 and prostacyclin, as well as to show antiplatelet aggregation action. It consequently improves symptoms such as paralysis of limbs caused by constriction of cerebral blood vessels after surgery for subarachnoid hemorrhage.
It is usually used to treat cerebral vasospasm and its accompanied symptoms of cerebral ischemia after surgery for subarachnoid hemorrhage.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have bleeding (hemorrhagic cerebral infarction, epidural bleeding, intra-cerebral bleeding, primary intraventricular bleeding), brain embolism, heart disease, cortical symptoms such as disturbance of consciousness or speech loss/agnosia, or large infarction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject this medicine intravenously over 24 hours.
  • In general, inject this medicine every day for 2 consecutive weeks.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include bleeding adverse drug reactions (subcutaneous bleeding, etc.), rash, hives, erythema, asthma (like) attack, itch, decreased blood pressure, anemia and fever. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • headache, bloody stool, subcutaneous bleeding [bleeding]
  • decreased blood pressure, respiratory distress, cold feeling  [shock, anaphylaxis]
  • general malaise, yellowing of skin and the white of eyes [liver dysfunction, jaundice]
  • prolonged bleeding, fever, chills [decreased platelets, leukopenia, granulocytopenia]
  • fever, general malaise, urination difficulty [renal dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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