くすりのしおり

Internal
Revised: 12/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Enalapril Maleate Tablets 5mg "Chemiphar"
 Active ingredient:
Enalapril maleate
 Dosage form:
light pink tablet, diameter : 6.5 mm, thickness : 2.3 mm
 Print on wrapping:
エナラプリルマレイン酸塩5mg「ケミファ」, Enalapril 5mg, 5, NPI R

Effects of this medicine

This medicine suppresses production of angiotensin II, which is a hypertensive substance, by inhibiting angiotensin-converting enzyme, and consequently decreases blood pressure. It also improves hemodynamics and raises cardiac output by decreasing peripheral vascular resistance, and consequently improves cardiac hypertrophy.
It is usually used in the treatment of various hypertensions and chronic heart failure (mild to moderate).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have a history of angioedema.
    If you have: renal disorder or cerebrovascular disorder (cerebral stroke etc.).
    If you are receiving apheresis or hemodialysis.
    If you are on a sodium restriction diet.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For patients with hypertension: In general, for adults, take 5 to 10 mg of the active ingredient at a time, once a day. The dosage may be adjusted according to the age or symptoms, however, in patients with renal or renal vascular hypertension, or malignant hypertension, the initial dose may be started at 2.5 mg at a time. For pediatric patients over 1 month after birth, take 0.08 mg/kg of the active ingredient at a time, once a day. Although the dosage may be adjusted according to the age or symptoms, the maximum daily dose is 10 mg.
    For patients with chronic heart failure: In general, for adults, take 1 to 2 tablets (5 to 10 mg of the active ingredient) at a time, once a day. The dosage may be adjusted according to the age or symptoms, however, in the patients with renal disorder or if you are taking diuretics, the initial dose may be started at 2.5 mg at a time.
    This preparation contains 5 mg of the active ingredient in a tablet. Strictly follow the instructions in any case.
  • If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Dizziness and light-headedness may occur due to an excessive decrease in blood pressure. Therefore, be aware of driving a car, working at heights, or operating dangerous machinery.
  • This medicine cannot be used by pregnant and possibly pregnant woman. If you become pregnant while taking this medicine, consult with your doctor immediately.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include dizziness and cough. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • breathing difficulty, swelling of the face, tongue or throat [angioedema]
  • facial pallor, cold sweat, orthostatic dizziness [shock]
  • chest pain, tightness, cold sweat [myocardial infarction, angina pectoris]
  • decreased urine output, general edema, malaise [acute renal disorder]
  • sore throat, fever, nose bleeding [pancytopenia, agranulocytosis, thrombocytopenia]
  • abdominal pain, nausea  [pancreatitis]
  • fever, dry cough, breathlessness [interstitial pneumonia]
  • erythema, blister, fever, itch [exfoliative dermatitis, toxic epidermal necrosis, mucocutaneous ocular syndrome, pemphigus]
  • impaired mind, unable to tell the time/place, hallucination [confusion]
  • general malaise, loss of appetite, nausea [liver dysfunction, liver failure]
  • muscular weakness, weakness, numbness in the limbs [hyperkalemia]
  • general malaise, frequent urination, thirst [syndrome of inappropriate secretion of antidiuretic hormone]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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