くすりのしおり

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Published: 9/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ESTRANA Tapes 0.09mg
 Active ingredient:
Estradiol
 Dosage form:
light orange oval tape, major axis: 1.3 cm, minor axis: 1.1 cm
 Print on wrapping:
HP374T

Effects of this medicine

This medicine replaces female hormone transdermally to improve vasomotor symptoms such as hot flush, hot flash and abnormal sweating due to decreased female hormones. It also improves bone density by suppressing bone resorption.
It is usually used to treat vasomotor symptoms (hot flush/sweating) and urogenital atrophy symptoms associated with climacteric disorder or ovarian deficiency symptoms, and postmenopausal osteoporosis, and for hypoestrogenism due to hypogonadism, gonadectomy or primary ovarian insufficiency.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have or are suspected of having estrogen-dependent tumors (breast cancer, endometrium cancer, etc.).If you have a history of breast cancer.If you have untreated endometrial hyperplasia, liver disorder or undiagnosed abnormal genital bleeding.If you have or have a history of thrombophlebitis/pulmonary embolism or arterial thromboembolic disease (coronary heart disease, stroke, etc.).
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For vasomotor symptoms (hot flush/sweating) and urogenital atrophy symptoms associated with climacteric disorder or ovarian deficiency symptom: In general, for adults, apply 0.72 mg of the active ingredient to the lower abdomen or the buttocks, and replace the old patch with a new patch every 2 days.
    For postmenopausal osteoporosis: In general, for adults, apply 0.72 mg of the active ingredient to the lower abdomen or the buttocks and replace the old patch with a new patch every 2 days.
    For hypoestrogenism due to hypogonadism, gonadectomy or primary ovarian insufficiency: In general, for adults, start by applying 0.72 mg of the active ingredient to the lower abdomen or the buttocks. The dosage may be adjusted according to the symptoms. The old patch should be replaced with a new patch every 2 days. For children, start by applying 0.09 mg of the active ingredient to the lower abdomen or the buttocks. The dosage will be increased step by step, to 0.18 mg, 0.36 mg, then 0.72 mg. The old patch should be replaced with a new patch every 2 days.
    This medicine contains 0.09 mg of the active ingredient in a patch. In any case, strictly follow the instructions.
  • Do not apply this medicine to areas with wound, eczema or dermatitis, or to the chest.
  • Avoid applying this medicine on the waistline because the patch may fall off due to friction with clothes.
  • If you miss a dose, use the missed dose as soon as possible. You should never use two doses at one time. Follow your regular dosing schedule from the next dose.
  • If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop using this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include breast tension, breast pain, atypical bleeding, withdrawal bleeding, vaginal discharge and erythema/itch of the applied area. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, hives, general malaise [anaphylaxis]
  • leg pain/edema, chest pain, shortness of breath [venous thromboembolism, thrombophlebitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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