くすりのしおり

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Published: 12/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DORMOLOL Combination Ophthalmic Solution"TS"
 Active ingredient:
Dorzolamide hydrochloride
Timolol maleate
 Dosage form:
limpid and colorless, slightly viscous, ophthalmic solution, (bottle) colorless 5mL, (cap) white
 Print on wrapping:

Effects of this medicine

This medicine lowers pressure in the eye by reducing production of aqueous humor by inhibiting carbonic anhydrase and blocking β-receptor.
It is usually used to treat glaucoma or ocular hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: bronchial asthma/history of bronchial asthma, bronchospasm, chronic obstructive pulmonary disease, heart failure, sinus bradycardia, atrioventricular block, cardiogenic shock, diabetes, renal disorder, liver dysfunction, or history of intraocular surgery.
    If you wear contact lenses.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, apply 1 drop at a time, twice a day. Strictly follow the instructions.
  • Before applying, wash your hands thoroughly with soap and running water. Pull down your lower eyelid so that the dropper tip dose not touch eye or eyelashes and apply the medicine. After applying, keep your eyes closed for 1 to 5 minutes pressing the inner corner of the eye lightly. Wipe off any excess liquid with a wet gauze or tissue immediately. If you need to apply other eye drops at the same time, wait more than 5 minutes.
  • If you miss a dose, apply the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should not apply two doses at one time.
  • If you accidentally apply more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop applying this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include stinging eyes, keratitis (eye pain, focus disorder, foreign body sensation in eyes), headache, bloodshot eyes, and blurred vision. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • foreign body sensation in eyes, eye pain, bloodshot eyes [ocular pemphigoid]
  • shortness of breath, breathing difficulty, wheezing (whistling sound) [bronchospasm, respiratory distress, respiratory failure]
  • respiratory distress, loss of consciousness, dizziness on standing up [heart block, congestive heart failure, cerebral ischemia, cardiac arrest, cerebrovascular disorder]
  • fever, facial erythema, general malaise [systemic lupus erythematosus]
  • fever, redness/erosion of mucosa, erythema [Stevens-Jonson syndrome, toxic epidermal necrolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store in a shading bag away from heat.
  • Discard the remainder. Do not store them.
  • To avoid improper use and quality loss, do not transfer this solution to any other bottle or container.
  • Do not use any other solution in this bottle.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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