くすりのしおり

Internal
Revised: 10/2021

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Imatinib Tablets 100mg "JG"
 Active ingredient:
Imatinib mesilate
 Dosage form:
smoky yellowish red to deep yellowish red tablet, diameter: 8.6 mm, thickness: 3.4 mm
 Print on wrapping:
(face) イマチニブ100「JG」, イマチニブ100, 100, JG G07
(back) Imatinib 100, イマチニブ錠100mg「JG」, 100, 食後に多めの水で服用

Effects of this medicine

This medicine inhibits abnormal action of tyrosine kinases that is involved in cell growth, and suppresses the growth of cancer cells.
It is usually used to treat chronic myelogenous leukemia, KIT (CD117)-positive gastrointestinal stromal tumor or Philadelphia chromosome-positive acute lymphocytic leukemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Chronic myelogenous leukemia: In general, for adults in chronic phase, take 4 tablets (400 mg of imatinib) at a time, once a day after meals. For adults in accelerated/acute phase, take 6 tablets (600 mg of imatinib) at a time, once a day after meals. The dosage may be adjusted according to your blood test result, age or symptoms. However, the maximum doses are 6 tablets (600 mg of imatinib) at a time, once a day for chronic phase, and 4 tablets (400 mg of imatinib) at a time, twice a day for accelerated/acute phase.
    KIT (CD117)-positive gastrointestinal stromal tumor: In general, for adults, take 4 tablets (400 mg of Imatinib) once a day after meals. It may be reduced according to your age or symptoms.
    Philadelphia chromosome-positive acute lymphocytic leukemia: In general, for adults, take 6 tablets (600 mg of imatinib) at a time, once a day after meals. The dosage may be adjusted according to your blood test result, age or symptoms.
    Strictly follow the instructions in any case.
  • Take the medicine with a large amount of water after meals.
  • If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Measure your weight periodically, and consult with your doctor if there is abnormal weight gain.
  • This medicine may cause dizziness, drowsiness or foggy vision. Pay attention when performing dangerous operations such as driving a car, operating machinery or working at heights.
  • Refrain from taking grapefruit juice or any food containing St. John's wort, since the medicinal effect of the medicine may be intensified or weakened.
  • Sexually active females should use birth control while taking this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, nausea, diarrhea, loss of appetite, superficial edema (on face or eyelids) and malaise. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemic symptoms, fever, bleeding tendency [bone marrow suppression]
  • headache, nausea, consciousness disorder [cerebral/subdural bleeding]
  • vomiting of blood, melena, black stool [gastrointestinal bleeding, gastric antral vascular ectasia]
  • melena, vomiting of blood, abdominal pain [gastrointestinal perforation, tumor bleeding]
  • general malaise, loss of appetite, yellowing of skin and mucosa [liver dysfunction, jaundice, liver failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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