くすりのしおり

Internal
Revised: 9/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
REXULTI tablets 2mg
 Active ingredient:
Brexpiprazole
 Dosage form:
pale green tablet, diameter: 6.1 mm, thickness: 2.7 mm
 Print on wrapping:
(Front) レキサルティ, Otsuka, 2mg, BRX2, (Back) レキサルティ錠2mg

Effects of this medicine

This medicine acts on receptors for neurotransmitters in the brain such as serotonin and dopamine, to suppress symptoms such as hallucination and delusion and to stabilize unstable mental status, and to improve symptoms such as lack of motivation and loss of interest.
It is usually used in the treatment of schizophrenia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have or have a history of heart/vascular disease, cerebrovascular disorder, hypotension, or convulsive disease such as epilepsy.
    If you have diabetes or if you or your family has a history of diabetes.
    If you have attempted suicide or suicidal ideation.
    If you have renal/liver disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with taking 1 mg of the active ingredient at a time, once a day and continue to take for at least 4 days. Then the dose will be increased to 1 tablet (2 mg) at a time, once a day. This preparation contains 2 mg of the active ingredient in a tablet. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause sleepiness, decreased attentiveness, concentration and reflex movements, etc. Avoid operating dangerous machinery, such as driving a car.
  • Pay attention that alcohol (drinking) may intensify medicinal effects.
  • Uncontrollable behavioral symptoms (impulse control disorders) may appear, including repetitive gambling despite adverse social consequences such as a ruined personal life, a pathological increase in sexual desire, repeated excessive unplanned shopping, and binge eating. If any of these symptoms appear, consult with your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include akathisia (cannot remain still), insomnia, headache, weight gain, tremor (trembling limbs), somnolence, agitation (overexcited (emotionally hyper and loud)), extrapyramidal disturbance (muscle stiffness, trembling limbs etc.), nausea, constipation, dizziness, and sedation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • sudden fever, trembling limbs, muscle stiffness [neuroleptic malignant syndrome]
  • moving/in-and-out of the tongue, continual chewing motions [tardive dyskinesia]
  • nausea/vomiting, constipation, abdominal bloating [paralytic ileus]
  • weakness, muscle pain, reddish brown urine [rhabdomyolysis]
  • thirst, excessive intake of water, excessive urination [hyperglycemia, diabetic ketoacidosis, diabetic coma]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacy or medical institution about how to discard the remainder.
  • [To family members] The patient may experience impulse control disorders such as pathological gambling, a pathological increase in sexual desire, repeated excessive unplanned shopping, and binge eating. Please pay attention to the patient's language and behavior, and if any of these symptoms appear, consult with the patient's doctor.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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