くすりのしおり

Internal
Revised: 3/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
GLIBENCLAMIDE TABLETS 1.25mg "TOWA"
 Active ingredient:
Glibenclamide
 Dosage form:
white tablet with split line, diameter: 6.0 mm, thickness: 1.9 mm
 Print on wrapping:
Tw534, グリベンクラミド「トーワ」, 1.25 mg

Effects of this medicine

This medicine works on the pancreas and promotes insulin secretion in order to lower blood glucose (sugar in the blood). It is usually used to treat non-insulin dependent diabetes mellitus. (Only when a patient does not sufficiently respond to diet/exercise therapy alone.)

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with ketosis (overbreathing, faint, tremor of the limbs), diabetic coma/precoma, insulin-dependent diabetes mellitus, liver/renal disorder, infection, serious injury, gastrointestinal disorder such as diarrhea and vomiting, or hypophysis/adrenal function disorder.
    If you are just after/before having surgery.
    If you are malnourished, starving, or debilitated.
    If you have irregular eating habit, or you do not eat enough.
    If you do hard muscular exercise, or drink a lot of alcohol.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, take 1 to 2 tablet (s) (1.25 to 2.5 mg of the active ingredient) once a day (before or after breakfast), or take 0.5 to 1 tablet (0.625 to 1.25 mg of the active ingredient) twice a day (before or after meals both in the morning and in the evening). The dosage should be increased according to your symptoms. But daily dosage should not exceed 8 tablets (10 mg of the active ingredient). Strictly follow the instructions of your doctor/pharmacist.
  • If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time. (Taking double dose may cause hypoglycemia) .
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. Hypoglycemic symptoms may occur.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause hypoglycemia. Hypoglycemic symptoms occurring during working at heights or driving a car may lead to accidents. Pay extra attention.
  • One of hypoglycemic symptoms such as consciousness disorder may occur. Be sure to let your family and friends know that you are taking this medicine.
  • When hypoglycemic symptom without consciousness disorder occurs, take sugar in general. If you are taking alfa-glucosidase inhibitor (Acarbose, Voglibose, Miglitol) in combination with this medicine and such symptom occurs, take glucose. If you are feeling faint, contact your doctor.
  • While taking this medicine, you need to undergo tests for glucose in blood and in urine periodically.
  • This medicine may lose effectiveness if you neglect your health or if you have accompanying infection. Make sure to follow the hospital's advice on your daily life.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, photosensitivity and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • lassitude, a sense of hunger, cold sweat, palpitation, headache, tremor of the limbs, light headedness, dizziness [hypoglycemia]
  • fever, sore throat [agranulocytosis]
  • dizziness on standing up, easy fatigability, dull headache, dizziness, dull, palpitation/shortness of breath when moving [hemolytic anemia]
  • yellowing of the skin and the white of eyes, dark urine, vomiting, nausea, loss of appetite, itch [hepatitis, hepatic function disorder, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunight, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacist or medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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