くすりのしおり

Injection
Published: 4/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DENOSINE 500mg for I.V. Infusion
 Active ingredient:
Ganciclovir
 Dosage form:
injection
 Print on wrapping:
N/A

Effects of this medicine

This medicine exerts its antiviral activity by inhibiting DNA replication in human cytomegalovirus.
It is usually used to treat cytomegalovirus infection in the setting of acquired immune deficiency syndrome, organ transplant (including of hemopoietic stem cell transplant), and malignancy.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have bone marrow depression.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Primary care: In general, this medicine is given by intravenous drip infusion twice a day.
    Maintenance care: In general, this medicine is given by intravenous drip infusion 5 times a week or every day.
    Treatment duration will be determined depending on the symptoms.

Precautions while taking this medicine

  • This medicine may cause convulsion, sedation, dizziness, ataxia, or confusion. Avoid driving a car or operating dangerous machinery.
  • In animal experiments, teratogenicity (potential risk of fetal malformation) and genotoxicity have been reported for this medicine. Appropriate birth control should be used during treatment period for women of child-bearing potential and during treatment as well as until 90 days after last injection for men.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include renal dysfunction, liver dysfunction, anemia, nausea/vomiting, headache, and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemic symptoms, fever, gum bleeding or nose bleeding [bone marrow depression, pancytopenia, aplastic anemia, leukopenia, neutropenia, anemia, decreased platelets]
  • abdominal pain, black stools, vomiting of blood [serious bleeding associated with decreased platelets (including gastrointestinal bleeding)]
  • decreased urine output, edema, loss of appetite [renal failure]
  • acute upper abdominal pain and low back pain, fever, nausea [pancreatitis]
  • acute high fever with shivering, joint pain, muscle pain [myelopathy such as sepsis and infection associated with immune system disorder]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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