くすりのしおり

Internal
Revised: 9/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Julina Tablets 0.5mg
 Active ingredient:
Estradiol
 Dosage form:
bright grayish-yellow tablet, diameter: 6 mm, thickness: 2.85 mm
 Print on wrapping:
(face) ジュリナ錠 0.5 mg, HM
(back) ジュリナ錠 0.5 mg, Julina 0.5 mg, 0.5 mg

Effects of this medicine

This medicine relieves symptoms due to decreased ovarian hormones by supplementing estradiol, a type of ovarian hormone. It also suppresses decreasing bone quantity.
It is usually used to treat hot flush, sweating or vaginal dryness associated with climacteric disorder/ovarian deficiency symptoms, or postmenopausal osteoporosis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have or are suspected of having estrogen-dependent cancers (breast cancer, cancer of endometrium, etc.).
    If you have untreated endometrial hyperplasia.
    If you have a past medical history of breast cancer.
    If you have or have a past medical history of thrombophlebitis, pulmonary embolism or arterial thromboembolic disease (coronary heart disease, stroke, etc.).
    If you have liver disorder or undiagnosed abnormal genital bleeding.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For symptoms associated with climacteric disorder/ovarian deficiency symptoms: In general, for adults, take 1 tablet (0.5 mg of the active ingredient) at a time, once a day. The dosage may be increased to 2 tablets (1.0 mg) at a time, once a day.
    For postmenopausal osteoporosis: In general, for adults, take 2 tablets (1.0 mg of the active ingredient) at a time, once a day.
    In any case, strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as you remember. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Some foreign studies report that in women who used estrogen plus progestogen the risk of developing breast cancer becomes higher and the risk is correlated to the duration of use. Therefore, if you use this medicine with progestogen, receive enough explanations of benefits and risks with the combination use by your doctor.
  • During administration, you may receive breast and gynecological examinations (including endometrial cytology and measurement of thickness of endometrium by ultrasound examination, in women with uterus) periodically.
  • You may experience atypical genital bleeding while taking this medicine. Usually, this symptom disappears while you continue taking this medicine. If bleeding occurs frequently or continues for a long time, consult with your doctor.
  • Avoid taking any food containing St. John's wort, since it may decrease the blood level of the medicine and diminish medicinal effects.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include genital discharge, breast discomfort, abdominal pain, genital bleeding, abdominal bloating, nipple pain and breast pain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • leg pain/edema, sudden dyspnea, shortness of breath, chest pain, dizziness, disturbed consciousness, paralysis of limbs, acute visual impairment, etc. [venous thromboembolism, thrombophlebitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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