くすりのしおり

Internal
Revised: 12/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Hysron-H Tablets 200 mg
 Active ingredient:
Medroxyprogesterone acetate
 Dosage form:
White tablets, diameter 9.0 mm, thickness 3.5 mm
 Print on wrapping:
KH405 HYSH 200 mg

Effects of this medicine

This medicine, a type of female hormone (luteal hormone), inhibits proliferation of hormone-dependent tumor cells by suppressing secretion of hormones that act on the pituitary gland and stimulate ovaries.
It is usually used in the treatment of breast cancer and uterine body cancer (endometrial cancer).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are within 1 week after surgery.
    If you have thrombotic disease (cerebral infarction, myocardial infarction, thrombophlebitis) (including history of the disease), arteriosclerosis, heart disease (heart valve disease, atrial fibrillation, endocarditis, heart failure, etc.).
    If you are administering other hormones. If you have undiagnosed genital bleeding, urinary tract bleeding or breast lesion, liver disorder or hypercalcaemia.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Breast cancer: In general, for adults, take 1 to 2 tablets [200 to 400 mg of the active ingredient] 3 times daily.
    Uterine body cancer (endometrial cancer): In general, for adults, take 400 to 600 mg of the active ingredient in 2 or 3 devided doses daily. This preparation contains 200 mg of the active ingredient in a tablet.
    The dosage may be adjusted according to the symptoms. Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Treatment with this medicine may cause thrombosis(impeded blood flow, caused by blood coagulation in the vessels),so you should visit your doctor and receive laboratory tests regularly.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include moon face, uterine bleeding, edema, palpitations, dry mouth, nausea / vomiting, acne, itching, rash, hoarseness, flushing and worsening of diabetes. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • pain/swelling of calf, chest pain, tongue tangling [thrombosis]
  • shortness of breath, edema, weight gain [congestive heart failure]
  • hives, difficulty breathing, light-headedness [anaphylaxis]
  • reduced visual acuity, bulging eyes, double vision, migraine [papilledema]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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