くすりのしおり

Internal
Revised: 12/2020

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DEPAKENE Tablets 100mg [medication for migraine]
 Active ingredient:
Sodium valproate
 Dosage form:
yellow tablet, diameter: 8.2 mm, thickness: 4.2 mm
 Print on wrapping:
KH102 100mg デパケン

Effects of this medicine

This medicine is considered to suppress development of migraine via gamma-aminobutyric acid (GABA, an inhibitory neurotransmitter) in the brain.
It is usually used in the treatment of migraine to prevent or relieve development of migraine. It does not improve migraine which has already developed.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with liver disorder, encephalopathy or coma of unknown cause, or urea cycle disorder.
    If you have a family history of infant death of unknown cause.
  • If you are pregnant, possible pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, take 4 to 8 tablets (400 to 800 mg of the active ingredient) daily, in two or three divided doses. The dosage may be adjusted according to the age or symptoms. However, the dosage is restricted up to 10 tablets (1,000 mg) a day. Strictly follow the instructions.
  • If you missed a dose, take a dose as soon as possible. After taking the medicine, wait about 4 hours to take the next dose. You should never take two doses at one time.
  • If you accidently took too much of the medicine (more than instructed), check with your doctor/pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • The medicine may cause drowsiness, lowering of attentiveness, concentration and reflex motor activities. Avoid driving a car or operating dangerous machinery.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include somnolence, ataxia (cannot coordinate leg and arm movements), headache, sleeplessness, restlessness, abnormal vision, nausea / vomiting, loss of appetite, stomach discomfort, constipation, rash, enuresis / frequent urination, malaise and bleeding from nose. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • acute decreased consciousness, general dullness / loss of appetite, yellowing of the skin and the white of eyes [serious liver disorder such as fulminant hepatitis, jaundice, fatty liver]
  • loss of memory, irrational behavior, struggle [consciousness disturbance associated with hyperammonemia]
  • general dullness, dizziness, bruise  [hemolytic anemia, pure red-cell aplasia, pancytopenia, serious thrombocytopenia, granulocytopenia]
  • intense abdominal pain, fever, nausea  [acute pancreatitis]
  • fever, bloodshot eyes, sores around the eyes and the lips, widespread skin redness and multiple breakable blisters  [toxic epidermal necrolysis, oculomucocutaneous syndrome]
  • dry cough, shortness of breath, fever [interstitial pneumonia, eosinophilic pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • This medicine is susceptible to moisture. Store with care, do not take out the tablet from the sheet or damage the package.
  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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