くすりのしおり

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Published: 11/2010

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Lepetan suppository 0.2mg
 Active ingredient:
Buprenorphine hydrochloride
 Dosage form:
White suppository, length: approx. 27 mm, diameter: approx. 8.7 mm
 Print on wrapping:
(face) 坐剤, レペタン坐剤0.2mg, (back) レペタン坐剤0.2mg, 坐剤, のまないこと (Do not swallow.)

Effects of this medicine

This medicine suppresses pain conduction in the central nervous system, providing a strong analgesic action.
It is usually used to relieve postoperative pain and pains due to various cancers.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have respiratory dysfunction, pulmonary function impairment, hepatic disorder, renal disorder, narcotic dependence, drug dependence, consciousness clouding due to head injury or brain lesion, increased intracranial pressure, biliary tract disease, proctitis, rectal bleeding or hemorrhoid.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For postoperative pain: In general, for adults, insert 2 suppositories (0.4 mg of active ingredient) into the rectum (anus) at a time. Use the medicine approximately every 8 to 12 hours as necessary. If you feel severe postoperative pain, tell your doctor. Strictly follow the instructions of your doctor and pharmacist.
    For cancer-related pain: In general, for adults, insert 1 or 2 suppositories (0.2 or 0.4 mg of active ingredient) into the rectum (anus) at a time. Use the medicine approximately every 8 to 12 hours as necessary. You may be instructed to use a lower dose when first using this medicine. Strictly follow the instructions of your doctor and pharmacist.
  • This medicine must only be used for rectal administration. Whenever possible, insert the suppository after defecation. Never swallow this medicine. After removing the suppository from the package sheet, insert it into the rectum from the round (thinner) end of the suppository.
  • If you miss a dose, use the dose as soon as you remember it and consult with your doctor or pharmacist. You should use the next dose at the instructed dosing interval. You should never use two doses at one time.
  • If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop using this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Remain at rest whenever possible after using this medicine because it may cause nausea, vomiting, dizziness or light-headedness when standing or walking after use. If you are administered this medicine at an outpatient visit to a hospital or clinic, rest for a while before returning home.
  • This medicine may cause sleepiness, dizziness, light-headedness or decreased attention, concentration and reflex movement. Do not drive a car, work at heights or engage in dangerous activities after using this medicine.
  • Refrain from consuming alcohol while using this medicine (alcohol may enhance the therapeutic effect of this medicine or cause adverse effects).

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include itching, rash, dizziness, nausea and vomiting. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • Shallow and rapid breathing leading to breathing difficulty, and breathing difficulty shortly after moving  [respiratory depression, breathing difficulty]
  • Abnormal downward or back placement of the tongue  [glossoptosis]
  • Facial pallor, breathing difficulty, skin or mucosa (especially in lips and nails) turns blue to dark violet  [shock]
  • Mild consciousness disorder with delusion and hallucination, subjective unfounded beliefs  [delirium, delusion]
  • Continuous use of a certain substance regardless of trying to stop using it  [dependence]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture (it is not necessary to store in a refrigerator).
  • Discard the remainder. Do not store them. Ask the pharmacist how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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