くすりのしおり

Internal
Revised: 12/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Glycoran Tablets 250mg
 Active ingredient:
Metformin hydrochloride
 Dosage form:
white tablet, diameter: 9.1 mm, thickness: 4.5 mm
 Print on wrapping:
(face) 302, (back) グリコラン, 250mg

Effects of this medicine

This medicine suppresses sugar production in the liver and prompts sugar utilization in the muscles in order to reduce sugar in the blood.
It is usually used to treat type 2 diabetes.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash etc.) to any medicines.
    If you have: any history of lactic acidosis, renal dysfunction, hepatic dysfunction, cardiovascular disorder (shock, heart failure, myocardial infaction, pulmonary embolism, etc.), lung dysfunction, tendency of getting hypoxemia, intake exessive alcohol, dehydration, gastrointestinal disorder (diarrhea, vomiting, etc.), ketosis, diabetic coma or precoma stage, type 1 deibetes, infection, pre or post operation, injury, state of bad nutrition, state of starvation, state of debility, pituitary gland malfunction, adrenal gland dysfunction.
    If you are on dialysis.
  • If you are pregnant, breastfeeding or possibly pregnant.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with 2 tablets (500 mg of the active ingredient) in 2 to 3 divided doses a day after meals. Maintenance dose is determined by monitoring the effect of treatment. However, the daily dose should not exceed 3 tablets (750 mg). Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow diet and exercise therapy instructed by your doctor because of basics of the diabetes treatment. Note that state of dehydration due to drinking too much of alcohol, fever, diarrhea, vomitting, bad nutrition, etc. many cause lactic acidosis.
  • The medicine may cause hypoglycemia symptoms. Pay attention when you work at heights, or drive a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, loss of appetite, abdominal pain, nausea, rash and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • gastrointestinal symptoms (nausea, vomiting, diarrhea), generalized fatigability, muscle pain, hyperpnea  [lactic acidosis]
  • sense of hunger, lassitude, cold sweating [hypoglycemia]
  • gneralized fatigability, loss of appetite, yellowness in the skin or conjunctiva  [hepatic dysfunction, jaundice]
  • pain/stiffness/numbness in the muscles of the limbs, weakness in limbs [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacy how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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