くすりのしおり

Internal
Published: 2/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
MESALAZINE Tablets 250mg "Chemiphar"
 Active ingredient:
Mesalazine
 Dosage form:
white to pale yellow tablet with grayish white to pale grayish yellow flecks, diameter: 9.5 mm, thickness: 4.8 mm
 Print on wrapping:
(Face)メサラジン錠250 mg「ケミファ」, メサラジン, 250, NCP 239
(Back)Mesalazine 250 mg, メサラジン「ケミファ」, 250, NCP 239

Effects of this medicine

This medicine eliminates active oxygen released from inflammatory cells and inhibits the synthesis of leukotriene, thereby suppressing progression of inflammation and tissue damage in intestinal tract.
It is usually used to treat ulcerative colitis and Crohn's disease.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: renal disorder or liver disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For ulcerative colitis: In general, for adults, take 6 tablets (1,500 mg of the active ingredient) a day in 3 divided doses, after meals. In the remission stage, however, you may be instructed to take the medicine once a day, as necessary. The dosage may be adjusted according to the age or symptoms, and the daily dose will not exceed 9 tablets (2,250 mg). In the active stage, however, you may be instructed to take 16 tablets (4,000 mg) a day in 2 divided doses, as necessary. For children, take 30 to 60 mg of the active ingredient per kilogram of body weight a day in 3 divided doses, after meals. The dosage may be adjusted according to the age or symptoms, and the daily dose will not exceed 9 tablets (2,250 mg).
    For Crohn's disease: In general, for adults, take 6 to 12 tablets (1,500 to 3,000 mg) a day in 3 divided doses, after meals. The dosage may be reduced according to the age or symptoms. For children, take 40 to 60 mg per kilogram of body weight a day in 3 divided doses, after meals. The dosage may be adjusted according to the age or symptoms.
    This preparation contains 250 mg of the active ingredient in a tablet. In any case, strictly follow the instructions.
  • You may split the tablet in half to take, however, the medicine is a controlled-release preparation. Swallow it without chewing.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • You may find some white substance in your stool, however, it is a water insoluble coating agent, ethyl cellulose, and you do not worry this.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include melena, hematochezia, abdominal pain, rash and fever. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, dry cough, respiratory distress [interstitial lung disease]
  • chest pain, fever, respiratory distress [myocarditis, pericarditis, pleuritis]
  • decreased urine output, edema, general malaise [interstitial nephritis, nephrotic syndrome, deteriorated renal function, acute renal failure]
  • general malaise, headache, gum bleeding/ subcutaneous bleeding [aplastic anemia, pancytopenia, agranulocytosis, thrombocytopenia]
  • nausea, loss of appetite, general malaise [hepatitis, liver dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from light, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacy or medical institution on how to discard the remainder.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.