くすりのしおり

Injection
Published: 6/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
RETHIO Injection 100mg
 Active ingredient:
Thiotepa
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine suppresses proliferation of cancer cells by inhibiting DNA synthesis in cells.
It is usually used for pretreatment of autologous hematopoietic stem cell transplantation in pediatric malignant solid tumors.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have severe infection.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, administer by intravenous drip infusion with melphalan over 24 hours, once a day for 2 days in a row with a drug cessation period of 5 days, and then repeat the administration for 2 days in a row.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include stomatitis, vomiting, nausea and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, chills, general malaise [infection]
  • acute high fever, sore throat, nose/gum bleeding, dizziness [myelosuppression]
  • bloody phlegm, blood mixed vomited material, bloody stool [bleeding]
  • breathing difficulty, increased body weight, edema [pulmonary edema, edema, fluid retention]
  • decreased urine output, edema, general malaise [renal dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.