くすりのしおり

Internal
Published: 11/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
METOANA Combination Tablets LD
 Active ingredient:
Anagliptin
Metformin hydrochloride
 Dosage form:
pale yellow oval tablet, major axis: 15.0 mm, minor axis: 6.4 mm, thickness: 5.3 mm
 Print on wrapping:
メトアナ配合錠LD, メトアナ配合錠, LD, 糖尿病のお薬, METOANA LD, アナグリプチン100mg/メトホルミン塩酸塩250mg, Sc125

Effects of this medicine

This medicine inhibits the enzyme (DPP-4) which degrades incretin, a hormone acting to maintain constant blood glucose levels, and enhances insulin secretion according to blood glucose levels. This medicine also suppresses production of glucose in the liver and enhances the use of glucose in the muscles, resulting in better blood glucose control.
It is usually used for the treatment of type 2 diabetes mellitus.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: a history of lactic acidosis, renal dysfunction, liver dysfunction, cardiovascular disorder, pulmonary dysfunction, excessive alcohol intake, dehydration, gastrointestinal disorder, ketosis, diabetic coma or precoma, type 1 diabetes mellitus, infection, injury, pituitary gland dysfunction or adrenal gland dysfunction.
    If you are receiving dialysis, just after/before having surgery, malnourished, starved or debilitated.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, twice a day, in the morning and in the evening. Strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow the instructions on dietary/exercise therapy.
  • Please note that excessive alcohol intake or dehydration is likely to increase the risk of lactic acidosis.
  • This medicine may cause hypoglycemic symptoms. Pay close attention when you perform dangerous operations such as working at heights, driving a car or operating machinery.
  • If episode of hypoglycemia occurs, take an adequate amount of sugar (sugar, glucose, soft drink, etc.). If you take an α-glucosidase inhibitors (medicines which delay absorption of sugar such as miglitol or acarbose) simultaneously taking this medicine, and episode of hypoglycemia occurs, take glucose.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, stomach discomfort, constipation, rash and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • gastrointestinal disorder, malaise, hyperpnea (over breathing) [lactic acidosis]
  • cold sweat, a sense of hunger, tremor of limbs [hypoglycemia]
  • stoppage of stool, abdominal pain, abdomen enlarged feeling [intestinal obstruction]
  • persistent severe abdominal pain, vomiting [acute pancreatitis]
  • blister, erosion [pemphigoid]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Do not store the remainder and consult your pharmacy or medical institution how to discard it.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.