くすりのしおり

Internal
Published: 5/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ORKEDIA TABLETS 2mg
 Active ingredient:
Evocalcet
 Dosage form:
pale yellow tablet, diameter: 7.2 mm, thickness: 3.3 mm
 Print on wrapping:
KH602, オルケディア 2mg, Orkedia 2mg

Effects of this medicine

This medicine directly acts on calcium receptors on parathyroid cells to suppress synthesis and secretion of parathyroid hormone (PTH), and it consequently decreases serum PTH and serum calcium.
It is usually used in the treatment of secondary hyperparathyroidism in patients undergoing maintenance dialysis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: hypocalcaemia or liver dysfunction.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start by taking 1 mg of the active ingredient at a time, once daily, then the dosage may be adjusted between 1 to 8 mg by observing PTH and serum calcium level. Depending on your condition, the dosage may start from 2 mg at a time, once daily. The maximum daily dose is limited to 12 mg. Dose should be increased by 1 mg at a time, at intervals of at least two weeks. Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and continue your regular dosing schedule on the next day. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • During the treatment, blood tests are performed regularly. Be sure to keep your visiting schedule.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hypocalcaemia, nausea, vomiting, stomach discomfort and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • numbness/seizure, feeling unwell, arrhythmia/decreased blood pressure [hypocalcaemia]
  • palpitation, chest discomfort, chest pain [prolonged QT interval]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep the medicine out of the reach of children. Store it away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.