くすりのしおり

Injection
Published: 4/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ORENCIA FOR I.V. INFUSION[Active polyarticular juvenile idiopathic arthritis]
 Active ingredient:
Abatacept (Genetical Recombination)
 Dosage form:
Color, diameter mm, thick mm
 Print on wrapping:

Effects of this medicine

This medicine blocks co-stimulatory signal between antigen presenting cells and T cells, resulting in blocking T-cell activation and cytokine production related to rheumatoid arthritis.
It is usually used to treat active polyarticular juvenile idiopathic arthritis which conventional treatments showed insufficient results.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have serious infectious disease.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, administer intravenously at an interval of 2 weeks for the first 3 doses and then every 4 weeks.
    Intravenous infusion takes about 30 minutes.

Precautions while taking this medicine

  • If you feel something is wrong such as breathlessness or itch during or after administration, consult with your doctor or nurse immediately.
    Chest X-ray or other examination should be done periodically in order to prevent severe adverse drug reaction during or after administration. However, if you have prolonged cough or fever, contact with your doctor before the next consultation day and see your doctor as soon as possible.
    Wash hands and gargle and regulate your daily life to prevent infectious disease. If you notice any unusual signs with your physical condition such as phlegm, sore throat, nasal discharge, congested nose, malaise, rash, itching of skin, shortness of breath or breathing difficulty, consult with your doctor, nurse or pharmacist.
    If you notice any unusual signs other than those above or notice any changes in your physical conditions, consult with your doctor, nurse or pharmacist.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include headache, blood pressure elevation, decreased blood pressure, hypertension, upper respiratory infection (including nasopharyngitis), upper respiratory tract inflammation, nausea, stomatitis, constipation, gastroenteritis, rash (including eczema, prurigo, erythema) ,sore throat, oral candidiasis, oral herpes and hypopyrexia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • phlegm, sore throat, nasal discharge, congested nose, malaise [serious infection disease (sepsis, pneumonia, bronchitis, cellulitis, urinary-tract infection)]
  • malaise, rash, itching of skin, shortness of breath, breathing difficulty  [serious hypersensitivity (shock, anaphylactoid symptoms)]
  • fever, dry cough, breathing difficulty, shortness of breath [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Consult with your doctor before you receive vaccination.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.