くすりのしおり

Internal
Revised: 10/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
TRERIEF OD Tablets 50mg
 Active ingredient:
Zonisamide
 Dosage form:
faintly yellowish white to pale yellowish white tablet, diameter: approx. 10.5 mm, thickness: approx. 3.8 mm
 Print on wrapping:
(face) トレリーフ OD 50 mg, トレリーフ OD, OD, 5omg
(back) TRERIEF OD 50 mg, トレリーフOD, 50mg, OD

Effects of this medicine

This medicine enhances/prolongs antiparkinsonian effect of levodopa by elevating dopamine level, and improves motor symptoms and circadian change of symptoms (wearing-off phenomenon) in Parkinson's disease.
It is usually used concomitantly with levodopa-containing products to treat Parkinson's disease.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 0.5 tablet (25 mg of the active ingredient) once a day, concomitantly with levodopa-containing products. For improvement of circadian change of symptoms in Parkinson's disease, take 1 tablet (50 mg) once a day, concomitantly with levodopa-containing products. Strictly follow the instructions.
  • The medicine is designed to be taken without a glass of water. Moisten the tablet with saliva on the tongue and crush it lightly with the tongue, then swallow it with saliva. Alternatively, it can be taken with a glass of water/lukewarm water like other general medicines.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause drowsiness, lack of attention/concentration/reflex action ability. Do not drive a car or operate dangerous machinery after taking this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include drowsiness, loss of appetite, dyskinesia, nausea, hallucination, loss of vitality, dizziness, lightheadedness, rash and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • sudden fever, muscle stiffness, shaking in limbs [malignant syndrome]
  • fever, widespread erythema/bulla, skin exfoliation [toxic epidermal necrolysis, mucocutaneous ocular syndrome, exfoliative dermatitis]
  • anemic symptoms, sore throat, general malaise, bleeding tendency [aplastic anemia, agranulocytosis, pure red cell aplasia, thrombopenia]
  • muscle pain in limbs, stiffness, numbness [rhabdomyolysis]
  • lower back pain, abdominal pain, bloody urine [calculus in kidney/urinary tract]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.