くすりのしおり

External
Revised: 4/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Mikeluna combination ophthalmic solution
 Active ingredient:
Carteolol hydrochloride
Latanoprost
 Dosage form:
clear,colorless to slightly yellow ophthalmic solution (in 3.5 mL plastic container), (bottle) colorless, (cap) orange
 Print on wrapping:

Effects of this medicine

This medicine decreases ocular pressure by increasing the drainage of fluid that adjusts ocular pressure and suppressing the production of the fluid through beta-blocking activity.
It is usually used to treat glaucoma or ocular hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have bradycardia, unsatisfactorily controlled heart failure, atrioventricular block, cardiogenic shock, symptoms or history of bronchial asthma and bronchospasm, chronic obstructive pulmonary disease, unsatisfactorily controlled diabetes mellitus, diabetic ketoacidosis, metabolic acidosis, aphakia, intraocular lens implant, endophthalmitis (iritis, uveitis) or possible occult herpes virus infection.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, apply one drop at one time, in each eye once a day. Strictly follow the instructions.
  • Do not apply this medicine more than once a day because the intraocular pressure-lowering effect of the medicine may be diminished if you apply the medicine frequently.
  • Pay attention to avoid allowing the tip of the container to touch any part of your eye when applying.
  • As a general rule, apply this medicine with the head tilted back. After applying, close your eyes softly, press the inner corner of your eyes gently for 1 to 5 minutes, and then open your eyes. The eyedrop around your eye may cause dark discoloration around the eye or extension or thickening of eyelashes. Wipe the any excess liquid off immediately with a wet gauze or tissue.
  • If you need to use other eye drops at the same time, apply this medicine last. Wait more than 10 minutes after applying the other eye drops. If you necessarily have to apply this medicine first, wait long enough before you apply the other eye drops.
  • If you miss a dose and realize that you have missed a dose by the end of that day, apply one drop at one time. However, if you realize on the next day that you have missed a dose, do not apply this medicine twice a day or 2 drops at one time.
  • If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop using this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Applying this medicine causes iris pigmentation followed by gradual progression, which will stop after discontinuing this medicine. However, the tone of color in the treated eye may be different compared with the other eye. If you become aware of the difference, consult with your doctor.
  • This medicine may temporarily cause foggy vision. Do not operate machinery or drive a car until the symptom resolves.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hyperemia (conjunctival hyperemia, ciliary hyperemia, etc.), eye irritation, eye itching (itch), eye pain, vision blurred (foggy vision), corneal disorder (keratitis etc.) and foreign body sensation in eyes. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • whistling breath, breathing difficulty [asthmatic attack]
  • slow pulse and dizziness followed by fainting [syncope]
  • slow pulse, shortness of breath, dizziness [bradyarrhythmia]
  • general malaise, respiratory distress, general edema, nausea [congestive heart failure]
  • chest pain, pressured feeling, cold sweat [coronary spastic angina]
  • change in the color of the iris [iris pigmentation]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Tighten the cap after use every time.
  • Keep out of the reach of children. Store away from direct sunlight and heat.
  • Store in the accompanying bag.
  • Discard the remainder. Do not store them.
  • The eye dropper only contains 2.5 mL of the medicine in a 3.5 mL container from the start.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.