くすりのしおり

Internal
Revised: 4/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
OLANZAPINE Tablets 5mg "SANWA"
 Active ingredient:
Olanzapine
 Dosage form:
white tablet, diameter: approx. 8.2 mm, thickness: approx. 3.9 mm
 Print on wrapping:
オランザピン錠5mg「三和」, オランザピン, 5mg, OLANZAPINE 5 "SANWA", オランザピン5mg「三和」

Effects of this medicine

This medicine acts on receptors for neurotransmitter in brain, and regulates the function of neurotransmitters.
It is usually used for the treatment of schizophrenia, for the improvement of manic symptoms and depressive symptoms in bipolar disorder and for gastrointestinal symptoms (nausea, vomiting) associated with chemotherapy medicine (such as cisplatin) for cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If the patient is in a coma.
    If you have: diabetes mellitus or a history of its disease.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For schizophrenia: In general, for adults, start with 1 to 2 tablets (5 to 10 mg of the active ingredient) at a time, once a day. The dosage is maintained on 2 tablets (10 mg) at a time, once a day, it may be adjusted according to age or symptoms. However, the daily dosage is up to 4 tablets (20 mg).
    For treatment of manic symptoms in bipolar disorder: In general, for adults, start with 2 tablets (10 mg of the active ingredient) at a time, once a day. The dosage may be adjusted according to age or symptoms. However, the daily dosage is up to 4 tablets (20 mg).
    For treatment of depressive symptoms in bipolar disorder: In general, for adults, start with 1 tablet (5 mg of the active ingredient) at a time, once a day, and then increase to 2 tablets (10 mg) at a time, once a day at bedtime in either case. The dosage may be adjusted according to age or symptoms. However, the daily dosage is up to 4 tablets (20 mg).
    For gastrointestinal symptoms (nausea, vomiting) associated with chemotherapy medicine (such as cisplatin) for cancer: In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, once a day in combination with other antiemetics. The dosage may be increased according to your condition. However, the daily dosage is up to 2 tablets (10 mg).
    In any case, strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause drowsiness, dizziness, dizziness on standing up, light headedness, and lack of attention, concentration and/or reflex action ability. Do not work at heights or operate dangerous machinery such as driving a car.
  • Pay attention that alcohol drinking may intensify medicinal or medical effects.
  • Pay attention that smoking may weaken medicinal or medical effects.
  • This medicine may cause weight gain. If you feel an increasing in your body weight, check with your doctor/pharmacist, then take action(s) for weight control such as improvement of dietary balance and exercising.
  • Patients with depressive symptoms in bipolar disorder may show behavioral changes such as suicidal ideation or aggression due to the nature of this disease. Therefore, patients and family members should keep close contact with your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include weight gain, somnolence, insomnia, constipation, akathisia (state of restlessness), increased appetite, dry mouth and malaise. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • dry mouth, excessive fluid intake/excessive urination, frequent urination [hyperglycemia, diabetic ketoacidosis, diabetic coma]
  • cold sweat, a sense of hunger, tremor of limbs [hypoglycemia]
  • muscle stiffness, sweating, acute fever [neuroleptic malignant syndrome]
  • muscle pain in limbs, stiffness, general malaise [rhabdomyolysis]
  • sore throat, fever, muscle pain [agranulocytosis, leucopenia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Do not store the remainder and consult your pharmacy or medical institution how to discard it.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.