くすりのしおり

External
Published: 4/2016

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
PROVOCHOLINE Powder for Inhalation Solution 100mg
 Active ingredient:
Methacholine chloride
 Dosage form:
white powder (Use-time dissolution type inhalation)
 Print on wrapping:
プロボコリン吸入粉末溶解用100mg

Effects of this medicine

This medicine causes contraction of bronchial smooth muscle and increase of bronchial secretion by acting on acetylcholine receptor.
It is usually used for the examination of bronchial airway hyperresponsiveness in case of diagnosis/severity assessment of bronchial asthma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: airflow limitation (exhalation difficulty), obvious respiratory distress, wheezing (whistling sound), history of myocardial/cerebral infarction within recent 3 months, hypertension, cerebral/aortic aneurysm, hyperthyroidism, cardiovascular disease with bradycardia, peptic ulcer disease, Addison's disease, gastrointestinal/urinary tract obstruction, epilepsy, Parkinsonism, hyperfunction of vagus nerve or myasthenia gravis.
    If you have examined bronchial airway hyperresponsiveness on the same day.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inhale an appropriate series of the diluted solution from low concentration within the limits of 0.039 to 25 mg/mL using a nebulizer. Strictly follow the instructions.
  • This medicine is bronchoconstrictor used only for inhalation of the examination of bronchial airway hyperresponsiveness.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include cough, respiratory distress, wheezing (whistling sound), respiratory sounds abnormal and choking sensation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • breathing difficulty, shortness of breath on exertion [respiratory distress]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.