くすりのしおり

Injection
Revised: 9/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
AmBisome 50mg for Intravenous Infusion
 Active ingredient:
Amphotericin B
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine exerts bactericidal effect by penetrating cell membrane of fungi (mold and yeast) and Leishmania protozoa and leaking cytoplasmic component.
It is usually used to treat fungemia, respiratory mycosis, fungal meningitis, disseminated mycosis, febrile neutropenia with suspected fungal infection and leishmaniasis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are under treatment with transfusion of white blood cells.
    If you have soy allergy.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, administer by intravenous infusion once a day.
  • The treatment period with ths medicine depends on your symptoms.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea, vomiting, chill, fever, diarrhea/loose stool, kidney dysfunction (decreased urine output, edema), abnormal hepatic function (general malaise, loss of appetite), allergic reaction and angioneurotic edema (acute swelling involving the lips, eyelids, tongue, mouth, face or neck). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • facial pallor, respiratory distress, hives [shock, anaphylaxis]
  • irritation of throat, difficulty in swallowing, respiratory distress [infusion-related reaction]
  • decreased urine output, edema, headache [serious kidney disorder such as kidney failure and toxic nephropathy]
  • loss of appetite, general malaise, yellowing of the skin and conjunctiva [serious liver dysfunction such as liver failure, jaundice and hyperbilirubinemia]
  • arrhythmia, general malaise, lassitude [hypokalemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • If you become unwell during injection, you should tell your doctor immediately.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.