くすりのしおり

Internal
Revised: 8/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
METFORMIN HYDROCHLORIDE Tablets 500mgMT "SANWA"
 Active ingredient:
Metformin hydrochloride
 Dosage form:
faint yellow tablet with a split line, major axis: 13.7 mm, minor axis: 8.7 mm, thickness: 6.1 mm
 Print on wrapping:
メトホルミン塩酸塩錠500mgMT「三和」, メトホルミン塩酸塩500mgMT, 500, 糖尿病のお薬, METFORMIN HYDROCHLORIDE 500 MT “SANWA”, メトホルミン塩酸塩500mgMT「三和」, Sc32

Effects of this medicine

This medicine promotes sugar utilization in the muscles and suppresses sugar production in the liver in order to reduce sugar in the blood (blood sugar level).
It is usually used for the treatment of type 2 diabetes mellitus.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: a history of lactic acidosis, renal dysfunction, liver dysfunction, cardiovascular disorder, pulmonary dysfunction, hypoxemia, excessive alcohol intake, dehydration, gastrointestinal disorder, ketosis, diabetic coma or precoma, type 1 diabetes mellitus, infection, injury, pituitary gland dysfunction, adrenal gland dysfunction.
    If you are receiving dialysis, just after/before having surgery, malnourished, starved or debilitated.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with 1 tablet (500 mg of the active ingredient) in 2 to 3 divided doses daily, either immediately before meals or after meals. The maintenance dose should be decided by judging the effectiveness of the medicine. Standard maintenance dose is 1.5 to 3 tablets (750 to 1,500 mg) in 2 to 3 divided doses daily. In general, for children aged 10 years or older, start with 1 tablet (500 mg) in 2 to 3 divided doses daily, either immediately before meals or after meals. The maintenance dose should be decided by judging the effectiveness of the medicine. Standard maintenance dose is 1 to 3 tablets (500 to 1,500 mg) in 2 to 3 divided doses daily. The dosage may be adjusted according to the symptoms. The maximum daily dose is 4.5 tablets (2,250 mg) for adults and 4 tablets (2,000 mg) for children aged 10 years or older. Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Please note that excessive alcohol intake or dehydration is likely to increase risk of lactic acidosis.
  • This medicine may cause hypoglycemic symptoms. Pay close attention when you perform dangerous operations such as driving a car, operating machinery or working at heights.
  • Make sure to have your family members understand that you are a patient with diabetes mellitus.
  • Strictly follow the instructions on dietary/exercise therapy.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, nausea, loss of appetite, abdominal pain, rash and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • gastrointestinal disorder, malaise, hyperpnea (over breathing) [lactic acidosis]
  • lassitude, severe sense of hunger, sweating [hypoglycemia]
  • general malaise, nausea, yellowing of the skin and the conjunctiva [liver dysfunction, jaundice]
  • muscle pain in limbs, stiffness, general malaise [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Do not store the remainder and consult your pharmacy or medical institution how to discard it.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.