くすりのしおり

Injection
Revised: 8/2012

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Epoetin Alfa BS Injection 750 "JCR" [Renal Anemia in Dialysis Patients]
 Active ingredient:
Epoetin kappa (genetical recombination) [Epoetin alfa biosimilar 1]
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine promotes differentiation/multiplication of red blood cells by binding to erythropoietin receptors developing mainly in erythroblastic precursor cells inside the spinal cord.
It is usually used to improve anemia in dialysis patients by increasing red blood cells.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have myocardial infarction, pulmonary infarction, cerebral infarction, hypertension or allergic predisposition.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject this medicine intravenously as slowly as possible 3 times a week in the early phase of treatment and 2 to 3 times a week after effects are obtained.
  • This medicine may be used for a long period of time depending the effects.
  • In cases where this medicine is used for the first time or after a long interval, a small amount may be injected intravenously to check for abnormalities.

Precautions while taking this medicine

  • Pay close attention to manage your blood pressure since this medicine may increase blood pressure.
  • This medicine may cause hyperkalemia. Follow adequate dietary control.
  • You need to take iron to get an effect. If you are prescribed iron preparation, you should take it as instructed by your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include increased blood pressure, headache and rash. If any of these symptoms occurs, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • hives, respiratory distress, lip edema [shock, anaphylactoid symptoms]
  • headache, disturbance of consciousness, convulsion [hypertensive encephalopathy, cerebral bleeding]
  • anginal pain, respiratory distress, sudden paralysis of one-sided limbs or face [myocardial infarction, pulmonary infarction, cerebral infarction]
  • palpitation or shortness of breath when walking up stairs or a slope, headache, general malaise [pure red cell aplasia]
  • yellow discoloration of the skin and the white of eyes, general malaise, loss of appetite [liver dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.